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Preliminary Evaluation of EVP 1001-1

2003; Lippincott Williams & Wilkins; Volume: 38; Issue: 10 Linguagem: Inglês

10.1097/01.rli.0000077057.88108.3f

1536-0210

Pippa Storey, Peter G. Danias, Mark J. Post, Wei Li, Peter R. Seoane, Phillip Harnish, Robert R. Edelman, Pottumarthi V. Prasad,

Ultrasound and Hyperthermia Applications

To investigate the potential of a novel manganese-based magnetic resonance (MR) contrast agent, EVP 1001-1 for the evaluation of myocardial ischemia.MR imaging with EVP 1001-1 was performed on 6 Yorkshire pigs, and T1 relaxation times were calculated. One animal served as a control, 2 were subjected to an acute coronary artery occlusion and 3 provided a model of chronic ischemia.Administration of the agent in the control and acute coronary occlusion model demonstrated a short plasma half-life (approximately 1.5 minutes) and rapid myocardial uptake in nonoccluded regions, with long retention times in the myocardium (>1 hour) and no evidence of redistribution. In the chronic ischemia model, differential enhancement was observed between normal and ischemic tissue, particularly under dobutamine-induced stress.These properties suggest the use of EVP 1001-1 for steady-state imaging of myocardial perfusion. Contrast administration could be performed under stress conditions outside the scanner, with high-resolution MR images reflecting the stress condition acquired after the stress has subsided.