Determination of blood lead in dried blood-spot specimens by Zeeman-effect background corrected atomic absorption spectrometry
1992; Royal Society of Chemistry; Volume: 117; Issue: 6 Linguagem: Inglês
10.1039/an9921700959
ISSN1364-5528
AutoresStephen T. Wang, Helen P. Demshar,
Tópico(s)Heavy metals in environment
ResumoA simple procedure for the determination of blood-lead levels in dried blood-spot filter-paper specimens is described. A 3/16 inch dried blood spot was analysed by a method involving extraction of the lead into 1.25%(NH4)2HPO4—0.5% Triton X-100 solution. A matrix-based calibration was used for analysis, with use of a Zeeman-effect background corrected atomic absorption spectrometer. The within-run precision (% relative standard deviation) of the method at the low end of the analytical range was 19% at 0.36 µmol dm–3 and 14% at 0.60 µmol dm–3. The accuracy of the method was verified by recovery tests and by comparison with a routine whole-blood method. The mean blood lead level of 425 Toronto newborns was 0.19 µmol dm–3(range 0–0.75 µmol dm–3).
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