Synergy between LRH-1 and β-Catenin Induces G1 Cyclin-Mediated Cell Proliferation
2004; Elsevier BV; Volume: 15; Issue: 4 Linguagem: Inglês
10.1016/j.molcel.2004.07.009
ISSN1097-4164
AutoresOronza A. Botrugno, Elisabeth Fayard, Jean‐Sébastien Annicotte, Céline Haby, Thomas J. Brennan, Olivia Wendling, Toshiya Tanaka, Tatsuhiko Kodama, Winston Thomas, Johan Auwerx, Kristina Schoonjans,
Tópico(s)Epigenetics and DNA Methylation
ResumoLRH-1 is an orphan nuclear receptor predominantly expressed in tissues of endodermal origin, where it controls development and cholesterol homeostasis. We show here that LRH-1 induces cell proliferation through the concomitant induction of cyclin D1 and E1, an effect that is potentiated by its interaction with β-catenin. Whereas β-catenin coactivates LRH-1 on the cyclin E1 promoter, LRH-1 acts as a potent tissue-restricted coactivator of β-catenin on the cyclin D1 promoter. The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the β-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells.
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