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Synthesis and biological evaluation of 2-alkoxyphenyl-6-(substituted phenyl)-1,3,4-thiadiazole-[3,2-a]-s-triazin-5,7-diones and 1-(alkyl and substituted phenyl)-3-[5-alkoxyphenyl-1,3,4-thia- and oxadiazol-2-yl]-ureas

1989; Elsevier BV; Volume: 24; Issue: 3 Linguagem: Inglês

10.1016/0223-5234(89)90010-x

1768-3254

Giovanni Puglisi, Rosario Pignatello, Annamaria Panico, G. MAZZONE, Antonino Corsaro, Antonina Caruso, Maria Grazia Leone, Matilde Amico‐Roxas,

Synthesis and Biological Evaluation

Abstract As an extension of a previous work, in which a series of 2-alkoxyphenyl-6-phenyl-1,3,4-thiadiazole-[3,2- a ]- s -triazin-5,7-diones were synthesized and found to possess analgesic activity, a new series of analogues substituted in the 6-phenyl ring has been prepared and tested with the aim of examining the variations induced by phenyl substituents in biological activity, and thus obtaining useful information about the structure—activity relationship. Together with the series of ureas precursor to title diones, the corresponding series containing a 5-alkoxyphenyloxadiazole nucleus in place of the thiadiazole moiety, and some alkyl ureas were also prepared and tested for biological activity.