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The utility of 99mTc-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors

2010; AEPress; Volume: 57; Issue: 1 Linguagem: Inglês

10.4149/neo_2010_01_068

1338-4317

S. Pavlović, Vera Artiko, Dragana Šobić-Šaranović, Svetozar Damjanović, Bojana Popović, Radoslav Jaković, Zorica Petrasinovic, Emilija Jakšić, Mila Todorovic‐Tirnanic, Dj. Saranovic, Marjan Micev, Sunčica Andreja Novosel, Neda Nikolić, Vladimir Obradović,

Gyrotron and Vacuum Electronics Research

Our aim was to assess clinical utility of 99m Tc-EDDA/HYNIC-TOC scintigraphy for evaluation of lung lesions in patients with neuroendocrine tumors (NETs).Single photon emission computed tomography (SPECT) of the thorax and whole body scintigraphy were performed in 34 patients using 99m Tc-EDDA/HYNIC-TOC.Visual assessment was complemented by semiquantitative evaluation based on tumor to non-tumor (T/NT) ratio.Clinical, laboratory, and histological findings served as the standard for comparison.Enhanced tracer uptake was observed on both SPECT and whole body scintigraphy in 29 of 34 patients (88% sensitivity).T/NT ratios were significantly higher on SPECT than whole body images (2.96±1.07vs.1.70±0.43,p<0.01) and did not correlate with NET proliferation index p=0.27).Conclusion: 99m Tc-EDDA/ HYNIC-TOC scintigraphy is useful for evaluation of NET tissue in the lungs.SPECT provides better visualization of lung lesions than whole body scintigraphy.The intensity of tracer uptake, however, does not relate to the proliferation rate of NETs.99m Tc-EDDA/HYNIC-TOC scintigraphy may be helpful for selecting and monitoring treatment options, particularly when radiolabeled somatostatin analogue therapy becomes available.