Signal Transduction in Normal and Malignant Melanocytes
1994; Wiley; Volume: 7; Issue: 2 Linguagem: Inglês
10.1111/j.1600-0749.1994.tb00026.x
ISSN1600-0749
Autores Tópico(s)Cutaneous Melanoma Detection and Management
ResumoPigment Cell ResearchVolume 7, Issue 2 p. 89-95 Signal Transduction in Normal and Malignant Melanocytes RUTH HALABAN, Corresponding Author RUTH HALABAN Department of Dermatology Yale University School of Medicine, New Haven, CT 06520-8059Address reprint requests to Dr. Ruth Halaban, Department of Dermatology, Yale University of Medicine, 333 Cedar Street, P.O. Box 208059, New Haven, CT 06520-8059.Search for more papers by this author RUTH HALABAN, Corresponding Author RUTH HALABAN Department of Dermatology Yale University School of Medicine, New Haven, CT 06520-8059Address reprint requests to Dr. Ruth Halaban, Department of Dermatology, Yale University of Medicine, 333 Cedar Street, P.O. Box 208059, New Haven, CT 06520-8059.Search for more papers by this author First published: April 1994 https://doi.org/10.1111/j.1600-0749.1994.tb00026.xCitations: 8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Adam, D., N. Dimitrijevic, and M. Schartl (1993) Tumor suppression in Xiphophorus by an accidentally acquired promoter. Science, 259: 816–819. Albino, A.P., B.M. Davis, and D. Nanus (1991) Induction of growth factor RNA expression in human malignant melanoma: Markers of transformation. Cancer Res., 51: 4815–4820. Albino, A.P., and J.W. Fountain. 1993. The molecular genetics of human malignant melanoma. In: Cancer Treatment and research: Basic and clinical aspects of malignant melanoma. L. Nathanson, ed. Nijhoff, Boston , Mass. , pp. 201–255. Anders, F., M. Schartl, A. Barnekow, and A. Anders (1984) Xiphophorus as an in vivo model for studies on normal and defective control of oncogenes. Adv. Cancer Res., 42: 191–275. Becker, D., P.L. Lee, U. Rodeck, and M. Hcrlyn (1992) Inhibition of the fibroblast growth factor receptor 1 (FGFR-1) gene in human melanocytes and malignant melanomas leads to inhibition of proliferation and signs indicative of differentiation. Oncogene, 7: 3202–3313. Becker, D., C.B. Meier, and M. Herlyn (1989) Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor. EMBO J., 8: 3685–3691. Bell, J.D., L.O. Buxton, and L.L. Brunton (1985) Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. J. Biol. Chem., 260: 2625–2628. Bennett, D.C. 1993) Genetics, development and malignancy of melanocytes. Int. Rev. Cytol., 146: 191–260. Birnbaum, D., and P. Gaudray (1989) Amplification of FGF-related genes in human tumors: Possible involvement of HST in breast carcinomas. Oncogene, 4: 915–922. Bischoff, J.R., P.N. Friedman, D.R. Marshak, C. Prives, and D. Beach (1990) Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc. Natl. Acad. Sci. USA, 87: 4766–4770. Blenis, J. (1993) Signal transduction via the MAP kinases: Proceed at your own RSK. Proc. Natl. Acad. Sci. USA 90: 5889–5892. Boulton, T.G., S.H. Nye, D.J. Robbins, N.Y. Ip, E. Radziejewska, S.D. Morgenbesser, R.A. DePinho, N. Panayotatos, M.H. Cobb, and G.D. Yancopoulos (1991) ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell, 65: 663–675. Bradl, M., A. Klein-Szanto, S. Porter, and B. Mintz (1991) Malignant melanoma in transgenic mice. Proc. Nat. Acad. Sci. USA, 88: 164–168. Bull, H.A., C.B. Bunker, G. Terenghi, D.R. Springall, Y. Zhao, J.M. Polak, and P.M. Dowd (1991) Endothelin-1 in human skin: Immunolocalization, receptor binding, mRNA expression, and effects on cutaneous microvascular endothelial cells. J. Invest. Dermatol., 97: 618–623. Cantley, L.C., K.R. Auger, C. Carpenter, B. Duckworth, A. Graziani, R. Kapeller, and S. Soltoff (1991) Oncogenes and signal transduction. Cell, 64: 281–302. Cobb, M.H., T.G. Boulton, and D.J. Robbins (1991) Extracellular signal-regulated kinases: ERKs in progress. Cell Regulation, 2: 965–978. Crews, C.M., and R.L. Erikson (1993) Extracellular signals and reversible protein phosphorylation: What to Mek of it all. Cell, 74: 215–217. Cross, M., and T.M. Dexter (1991) Growth factors in development, transformation, and tumorigenesis. Cell, 64: 271–280. De Groot, R.P., and P. Sassone-Corsi (1993) Hormonal control of gene expression: Multiplicity and versatility of cyclic adenosine 3′,5′-monophosphate-responsive nuclear regulators. Mol. Endocrinol., 7: 145–153. De Vries-Smits, A.M.M., B.M.T. Burgering, S.J. Leevers, C.J. Marshall, and J.L. Bos (1992) Involvement of p21ras in activation of extracellular signal-regulated kinase 2. Nature, 357: 602–604. Dean, M., M. Park, M.M. Le Beau, T.S. Robins, M.O. Diaz, J.D. Rowley, D.G. Blair, and G.F. Vande Woude (1985) The human met oncogene is related to the tyrosine kinase oncogenes. Nature, 318: 385–388. Dotto, G.-P., G. Moellmann, S. Ghosh, M. Edwards, and R. Halaban (1989) Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phonotypa in a reconstituted cutaneous environment. J. Cell Biol., 109: 3115–3128. Forsberg, K., I. Valyi-Nagy, C.-H. Heldin, M. Herlyn, and B. Westermark (1993) Platelet-derived growth factor (PDGF) in oncogenesis: Development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc. Natl. Acad. Sci. USA, 90: 393–397. Fountain, J.W., S.J. Bale, D.E. Housman, and N.C. Dracopoli (1990) Genetics of melanoma. Cancer Surv., 9: 645–671. Fu, X.-Y., and J.-J. Zhang (1993) Transcription factor p91 interacts with the Epidermal Growth factor Receptor and mediates activation of the c-fos gene promoter. Cell, 74: 1135–1145. Funasaka, Y.B.T.M., Cobb, Y. Y., B. Fan, S.D. Lyman, D.E. Williams, D.M. Anderson, R. Zakut, Y. Mishima, and R. Halaban (1992) C-Kit kinase induces a cascade of protein tyrosine-phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down regulated in melanomas. Mol. Biol. Cell, 3: 197–209. Ginty, D.D., M.M. Kornhauser, M.A. Thompson, H. Bading, K.E. Mayo, J.S. Takahashi, and M. Greenberg (1993) Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science, 260: 238–241. Gonzalez, G.A., K.K. Yamamoto, W.H. Fischer, D. Karr, P. Menzel, W. Biggs III, W.W. Vale, and M.R. Montminy (1989) A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature, 337: 749–752. Halaban, R. 1992. Receptor tyrosine protein kinases in normal and malignant melanocytes. In: The biology of the epidermis. A. Okhawara and J. McGuire, eds. Elsevier Sciences Publishers B.V., Amsterdam , pp. 133–140. Halaban, R. 1993a. Growth factors and receptors in normal melanocytes and melanoma cells, A review. In: Pharmacology of the skin. B. A. Bernard and B. B. Shroot, eds. Karger AG, Basel , pp. 139–145. Halaban, R. 1993b. Growth regulation in normal and malignant melanocytes. In: Recent Results in Cancer Research. E. Hecker, F. Marks, E.G. Jung and W. Tilgen, eds. Springer-Verlag, Berlin – Heidelberg , pp. 133–149. Halaban, R. (1993c) Molecular correlates in the progression of normal melanocytes to melanomas. Semin. Cancer Biol. 4: 171–181. Halaban, R.B.A., Fan J., Y. Funasaka, H. Gitay-Goren, and N.G. (1992) Growth factors, receptor kinases and protein tyrosine phosphatases in normal and malignant melanocytes. J. Immunother., 12: 154–162. Halaban, R., Y. Funasaka, P. Lee, J. Rubin, D. Ron, and D. Birnhaum (1991) Fibroblast growth factors in normal and malignant melanocytes. Ann. NY Acad. Sci. 638: 232–243. Halaban, R., S. Ghosh, and A. Baird (1987) Bfgf is the putative natural growth factor for human melanocytes. In Vitro Cell. Dev. Biol. 23: 47–52. Halaban, R., R. Langdon, N. Birchall, C. Cuono, A. Baird, G. Scott, G. Moellmann, and J. McGuire (1988b) Basic fibroblast growth factor of keratinocytes is a natural mitogen for normal human melanocytes. J. Cell Biol., 107: 1611–1619. Halaban, R., B.S. Kwon, S. Ghosh, P. Delli Bovi, and A. Baird (1988a) Bfgf as an autocrine growth factor for human melanoma. Oncogene Res., 3: 177–186. Halaban, R., and G. Moellmann (1993a) Fibroblast growth factors. In: Epidermal growth factors. T. Luger and T. Schwartz, eds. Marcel Dekker, New York pp. 273–289. Halaban, R., and G. Moellmann (1993b) White mutants in mice shedding light on humans. J. Invest. Dermatol., 100 (suppl.): 176s–185s. Halaban, R., J. Rubin, Y. Funasaka, M. Cobb, T. Boulton, D. Falsetto, E. Rosen, Al. Chan, K. Yoko, W. White, C. Cook, and G. Moellmann (1992) Met and hepatocyte growth factor/scatter factor signal transduction in normal melanocytes and melanoma cells. Oncogene, 7: 2195–2206. Halaban, R., W. Rubin, and W. White (1993a) Met and HGF/SF in normal melanocytes and melanoma cells. In: Hepatocyte growth factor-scatter factor and the C-Met receptor. I.D. Goldberg, ed. Birkhäuser Verlag, Basel , pp. 329–339. Halaban, R., L. Tyrrell, J. Longley, Y. Yarden, and J. Rubin (1993b) Pigmentation and proliferation of human melanocytes and the effect of MSH and UVB light. Ann. NY Acad. Sci. 680: 290–301. Henderson, B.E., R.K. Ross, and M.C. Pike (1991) Toward the primary prevention of cancer. Science, 254: 1131–1138. Horikawa, T., K. Nishino, and Y. Mishima (1991) Melanocyte growth factor in normal human skin. Pigment Cell Res., 4: 48–51. Hu, Q., J.A. Lees, K.J. Buchkovich, and E. Harlow (1992) The retinoblastoma protein physically associates with the human cdc2 kinase. Mol. Cell. Biol., 12: 971–980. Imokawa, G., Y. Yada, and M. Miyagishi (1992) Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. J. Biol. Chem., 267: 24675–24680. Iwamoto, T., M. Takahashi, M. Ito, K. Hamatani, M. Ohbayashi, W. Wajjwalku, K. Isobe, and I. Nakashima (1991) Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J, 10: 3167–3175. Kitagawa, M., S. Saitoh, H. Ogino, T. Okabe, H. Matsumoto, A. Okuyama, K. Tamai, Y. Ohba, H. Yasuda, S. Nishimura, and Y. Taya (1992) Cdc2-like kinase is associated with retinoblastoma. Oncogene, 7: 1067–1074. Koprowski, H., M. Herlyn, G. Balaban, A. Parmiter, A. Ross, and P. Nowell (1985) Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma. Som. Cell Mol. Genet., 11: 297–302. Krämer, M., C. Sachsenmaier, P. Herrlich, and H.J. Rahmsdorf (1993) UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response. J. Biol. Chem., 268: 6734–6741. Lange-Carter, C.A., C.M. Pleiman, A.M. Gardner, K.J. Blumer, and G.L. Johnson (1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science, 260: 315–319. Longley, J., C.S. Morganroth, L. Tyrell, T.G. Ding, D.M. Anderson, D.E. Williams, and R. Halaban (1993) Altered metabolism of mast cell growth factor (c-kit ligand) in cutaneous mastocytosis. N. Engl. J. Med., 328: 1302–1307. McGlade, J., A. Cheng, G. Pelicci, P.G. Pelicci, and T. Pawson (1992) She proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. Proc. Natl. Acad. Sci. USA, 89: 8869–8873. Milner, J., A. Cook, and J. Mason (1990) P53 is associated with p34 cde2 in transformed cells. EMBO J., 9: 2885–2889. Milner, J., J. Gamble, and A. Cook (1989) P53 is associated with a 35 kD protein in cells transformed by simian virus 40. Oncogene, 4: 665–668. Mintz, B., and W.K. Silvers (1993) Transgenic mouse model of malignant skin melanoma. Proc. Natl. Acad. Sci. USA, 90: 8817–8821. Mintz, B., W.K. Silvers, and A.J.P. Klein-Szanto (1993) Histopathogenesis of malignant skin melanoma induced in genetically susceptible transgenic mice. Proc. Natl. Acad. Sci. USA, 90: 8822–8826. Pardee, A. (1989) G1 events and regulation of cell proliferation. Science, 246: 603–608. Pelech, S.L., and J.S. Sanghera (1992) MAP kinases: Charting the regulatory pathways. Science, 257: 1355–1356. Pendergast, A.M., L.A. Quilliam, L.D. Cripe, C.H. Bassing, Z. Dai, N. Li, A. Batzer, K.M. Rabun, C.J. Der, J. Schlessinger, and M.L. Gishizky (1993) BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 Domain of the GRB-2 adaptor protein. Cell, 75: 175–185. Qiu, F., P. Ray, K. Brown, P.E. Barker, S. Jhanwar, F.H. Ruddle, and P. Besmer (1988) Primary structure of c-kit: Relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and c-terminus. EMBO J., 6: 1003–1011. Robbins, D.J.M., Cheng, Z. E., C.A. Vanderbilt, L.A. Feig, and M.H. Cobb (1992) Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc. Natl. Acad. Sci. USA, 89: 6924–6928. Rodeck, R., K. Melber, R. Kath, H.-D. Menssen, M. Varello, B. Atkinson, and M. Herlyn (1991) Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes. J. Invest. Dermatol., 97: 20–26. Rodeck, U., M. Herlyn, H.D. Menssen, R.W. Furlanetto, and H. Koprowski (1987) Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors. Int. J. Cancer, 40: 687–690. Rodeck, U., H.D. Menssen, and M. Herlyn (1988) Growth factors in the pathogenesis of malignant diseases. Dtsch. Med. Wochenschr. 113: 904–906. Schulze-Osthoff, K., W. Risau, E. Vollmer, and S. Clemens (1990) In situ detection of basic fibroblast growth factor by highly specific antibodies. Am. J. Pathol. 173: 85–92. Scott, G., M. Stoler, S. Sarkar, and R. Halaban (1991) Localization of basic fibroblast growth factor mRNA in melanocytic lesions by in situ hybridization. J. Invest. Dermatol., 96: 318–322. Sheng, M., M.A, Thompson, and M.E. Greenberg (1991) CREB: A Ca2+ -regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science, 252: 1427–1430. Shuai, K., G.R. Stark, I.M. Kerr, and J.E. Darnell Jr. (1993) A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science, 261: 1744–1746. Stierner, U., I. Rosdahl, A. Augustsson, and B. Kågedahl (1989) UVB irradiation induces melanocyte increase in both exposed and shielded human skin. J. Invest. Dermatol., 92: 561–564. Westermark, B., A. Johnson, Y. Paulsson, C. Betsholtz, C.-H. Heldin, M. Herlyn, U. Rodeck, and H. Koprowski (1986) Human melanoma cells lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor. Proc. Natl. Acad. Sci. USA, 83: 7197–7200. Williams, N.G., E. Paradis, S. Agarwal, D.L. Charest, S.L. Pelech, and T.M. Roberts (1993) Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA, 90: 5772–5776. Yada, Y., K. Higuchi, and G. Imokawa (1991) Effects of endothelins on signal transduction and proliferation in human melanocytes. J. Biol. Chem., 266: 18352–18357. Yamamoto, K.K., G.A. Gonzalez, W.H. Biggs III, and M.R. Montminy (1988) Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature, 334: 494–497. Yarden, Y., W-J. Kuang, T. Yang-Feng, L. Coussens, S. Munemitsu, T.J. Dull, E. Chen, J. Schlessinger, U. Francke, and A. Ullrich (1987) Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J., 6: 3341–3351. Yohn, J.J. (1993) Cultured human keratinocytes synthesize and secrete endothelin-1. J. Invest. Dermatol., 100: 23–26. Zakut, R., R. Perlis, S. Eliahu, Y. Yarden, D. Givol, S.D. Lyman, and R. Halaban (1993) KIT-ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene, 8: 2221–2229. Citing Literature Volume7, Issue2April 1994Pages 89-95 ReferencesRelatedInformation
Referência(s)