Portal de Periódicos da CAPES

Clearance of amyloid-β by circulating lipoprotein receptors

2007; Nature Portfolio; Volume: 13; Issue: 9 Linguagem: Inglês

10.1038/nm1635

1546-170X

Abhay P. Sagare, Rashid Deane, Robert D. Bell, B. J. Johnson, Katie Hamm, Ronan Pendu, Andrew Marky, Peter J. Lenting, Zhenhua Wu, Troy J. Zarcone, Alison Goate, Kevin H. Mayo, David D. Perlmutter, Mireia Coma, Zhihui Zhong, Berislav V. Zloković,

Diabetes Treatment and Management

Low-density lipoprotein receptor–related protein-1 (LRP) on brain capillaries clears amyloid β-peptide (Aβ) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for Aβ in humans. Recombinant LRP cluster IV (LRP-IV) bound Aβ in plasma in mice and Alzheimer's disease–affected humans with compromised sLRP-mediated Aβ binding, and reduced Aβ-related pathology and dysfunction in a mouse model of Alzheimer disease, suggesting that LRP-IV can effectively replace native sLRP and clear Aβ.