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Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women

2014; Nature Portfolio; Volume: 5; Issue: 1 Linguagem: Inglês

10.1038/ncomms5682

2041-1723

Kexin Chen, Hongxia Ma, Jingmei Li, Rongyu Zang, Cheng Wang, Fengju Song, Tingyan Shi, Dianke Yu, Ming Yang, Wen‐Qiong Xue, Juncheng Dai, Shuang Li, Hong Zheng, Chen Wu, Ying Zhang, Xiaohua Wu, Dake Li, Fengxia Xue, Haixin Li, Zhi Jiang, Jibin Liu, Yuexin Liu, Pei Li, Wen‐Hann Tan, Jing Han, Jie Jiang, Quan Hao, Zhibin Hu, Dongxin Lin, Ding Ma, Wei‐Hua Jia, Hongbing Shen, Qingyi Wei,

RNA modifications and cancer

Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (Pmeta<10−4) in 960 EOC cases and 1,799 controls (stage II), and an additional 492 EOC cases and 1,004 controls (stage III). Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, Pmeta=1.88 × 10−8) and 10p11.21 (rs1192691 near ANKRD30A, Pmeta=2.62 × 10−8), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, Pmeta=1.14 × 10−7) and 9q34.2 (rs633862 near ABO and SURF6, Pmeta=8.57 × 10−7) (P<0.05 in all three stages). These results may advance our understanding of genetic susceptibility to EOC. Ovarian cancer is common among women and is the leading cause of death from gynaecological malignancies. Here the authors identify two previously unknown genetic variants that increase the risk of epithelial ovarian cancer in Han Chinese women.