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Atherosclerosis: An update

1996; Elsevier BV; Volume: 131; Issue: 6 Linguagem: Inglês

10.1016/s0002-8703(96)90096-4

1097-6744

Bassem Jamil Basha, James R. Sowers,

Adipokines, Inflammation, and Metabolic Diseases

CHD remains the leading cause of death in most developed countries; therefore, elucidation of risk factors and associated mechanisms for atherosclerosis and development of CHD has been a high priority. Data from the Framingham Heart Study and other large-scale epidemiologic studies have identified major risk factors associated with CHD, demonstrating the adverse effects of increased total and LDL-C levels and the protective effect of HDL-C. Other endogenous and exogenous risk factors have been identified and are discussed in this review. In addition, we address known mechanisms involved in the atherosclerotic process.