Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine
2008; Portland Press; Volume: 115; Issue: 1 Linguagem: Inglês
10.1042/cs20070226
ISSN1470-8736
AutoresGrit Sommer, Antje Garten, Stefanie Petzold, Annette G. Beck‐Sickinger, Matthias Blüher, Michael Stümvoll, Mathias Faßhauer,
Tópico(s)Adipose Tissue and Metabolism
ResumoOver the last few years, it has become obvious that obesity and insulin resistance are linked by a variety of proteins secreted by adipocytes. Visfatin/PBEF (pre-B-cell colony-enhancing factor) has recently been identified as a novel adipokine with insulin-mimetic effects. Furthermore, an enzymatic function has been reported that reveals visfatin/PBEF as Nampt (nicotinamide phosphoribosyltransferase; EC 2.4.2.12.). Moreover, reports on the structure and hormonal regulation of visfatin/PBEF/Nampt have given further insights into its potential physiological role. The present review summarizes studies on visfatin/PBEF/Nampt as a novel adipokine.
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