Synthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry
2000; American Chemical Society; Volume: 43; Issue: 21 Linguagem: Inglês
10.1021/jm000316h
ISSN1520-4804
AutoresJosephine Liu, Dennis Underwood, Margaret A. Cascieri, Susan P. Rohrer, Louis‐David Cantin, Gary G. Chicchi, Amos B. Smith, Ralph Hirschmann,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTSynthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of PseudosymmetryJosephine Liu, Dennis J. Underwood, Margaret A. Cascieri, Susan P. Rohrer, Louis-David Cantin, Gary Chicchi, Amos B. Smith, and Ralph HirschmannView Author Information Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, DuPont Pharmaceutical Company, Wilmington, Delaware 19880, and Merck Research Laboratories, Rahway, New Jersey 07065 Cite this: J. Med. Chem. 2000, 43, 21, 3827–3831Publication Date (Web):September 29, 2000Publication History Received24 July 2000Published online29 September 2000Published inissue 1 October 2000https://pubs.acs.org/doi/10.1021/jm000316hhttps://doi.org/10.1021/jm000316hrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views234Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Agonists,Antagonists,Peptides and proteins,Receptors,Screening assays Get e-Alerts
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