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Facts, myths and hypotheses on the zoonotic nature of Mycobacterium avium subspecies paratuberculosis

2014; Elsevier BV; Volume: 304; Issue: 7 Linguagem: Inglês

10.1016/j.ijmm.2014.07.006

1618-0607

Raja Atreya, Michael Bülte, Gerald-F. Gerlach, Ralph Goethe, Mathias W. Hornef, Heike Köhler, Jochen Meens, Petra Möbius, Elke Roeb, Siegfried Weiß,

Infectious Diseases and Mycology

Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of paratuberculosis (Johne's disease [JD]), a chronic granulomatous enteritis in ruminants. JD is one of the most widespread bacterial diseases of domestic animals with significant economic impact. The histopathological picture of JD resembles that of Crohn's disease (CD), a human chronic inflammatory bowel disease of still unresolved aetiology. An aetiological relevance of MAP for CD has been proposed. This and the ambiguity of other published epidemiological findings raise the question whether MAP represents a zoonotic agent. In this review, we will discuss evidence that MAP has zoonotic capacity.