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Human Serum Adiponectin Levels are not Under Short-Term Negative Control by Free Fatty Acids in Vivo

2002; Thieme Medical Publishers (Germany); Volume: 34; Issue: 10 Linguagem: Inglês

10.1055/s-2002-35423

1439-4286

Harald Staiger, Otto Tschritter, Christiana Kausch, Reiner Lammers, Michael Stümvoll, H.-U. Häring,

Metabolism, Diabetes, and Cancer

Plasma levels of free fatty acids (FFAs) are elevated when adipose tissue expands and adipocytes become refractory to inhibition of lipolysis by insulin. FFAs have been known for years to have multiple effects on peripheral tissues such as glucose uptake and glycogen synthesis inhibition in skeletal muscle, hepatic gluconeogenesis stimulation, and insulin clearance impairment, altogether favoring whole body insulin resistance, hyperinsulinemia, hyperglycemia, and finally type 2 diabetes mellitus. Besides these metabolic effects, FFAs seem to be able to regulate adipocytokine gene expression. FFAs were shown to repress the expression of the recently discovered adipocyte hormone resistin in an insulin-resistant rat model [1]. In in vitro differentiated adipocytes, FFAs also downregulated the expression of leptin, the most important central regulator of energy expenditure and food intake known to date [2]. This effect of FFAs on gene expression might be mediated by direct activation of specific fatty acid-regulated transcription factors (for review, see [3]).