Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice
2000; Wiley; Volume: 60; Issue: 2 Linguagem: Inglês
10.1002/(sici)1097-4547(20000415)60
ISSN1097-4547
AutoresTakahiro Moriya, Yuko Yoshinobu, Yasuko Kouzu, Akira Katoh, Hiroshi Gomi, Masayuki Ikeda, Tohru Yoshioka, Shigeyoshi Itohara, Shigenobu Shibata,
Tópico(s)Stress Responses and Cortisol
ResumoJournal of Neuroscience ResearchVolume 60, Issue 2 p. 212-218 Article Involvement of glial fibrillary acidic protein (GFAP) expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice Takahiro Moriya, Corresponding Author Takahiro Moriya [email protected] human.waseda.ac.jp Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanAdvanced Research Center for Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa-shi, Saitama 359-1192, JapanSearch for more papers by this authorYuko Yoshinobu, Yuko Yoshinobu Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this authorYasuko Kouzu, Yasuko Kouzu Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this authorAkira Katoh, Akira Katoh RIKEN BSI, Wako-shi, Saitama, JapanSearch for more papers by this authorHiroshi Gomi, Hiroshi Gomi RIKEN BSI, Wako-shi, Saitama, JapanSearch for more papers by this authorMasayuki Ikeda, Masayuki Ikeda Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this authorTohru Yoshioka, Tohru Yoshioka Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, Japan Department of Molecular Neurobiology, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this authorShigeyoshi Itohara, Shigeyoshi Itohara RIKEN BSI, Wako-shi, Saitama, JapanSearch for more papers by this authorShigenobu Shibata, Shigenobu Shibata Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, Japan Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this author Takahiro Moriya, Corresponding Author Takahiro Moriya [email protected] human.waseda.ac.jp Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanAdvanced Research Center for Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa-shi, Saitama 359-1192, JapanSearch for more papers by this authorYuko Yoshinobu, Yuko Yoshinobu Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this authorYasuko Kouzu, Yasuko Kouzu Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this authorAkira Katoh, Akira Katoh RIKEN BSI, Wako-shi, Saitama, JapanSearch for more papers by this authorHiroshi Gomi, Hiroshi Gomi RIKEN BSI, Wako-shi, Saitama, JapanSearch for more papers by this authorMasayuki Ikeda, Masayuki Ikeda Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this authorTohru Yoshioka, Tohru Yoshioka Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, Japan Department of Molecular Neurobiology, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this authorShigeyoshi Itohara, Shigeyoshi Itohara RIKEN BSI, Wako-shi, Saitama, JapanSearch for more papers by this authorShigenobu Shibata, Shigenobu Shibata Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, Japan Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa-shi, Saitama, JapanSearch for more papers by this author First published: 29 March 2000 https://doi.org/10.1002/(SICI)1097-4547(20000415)60:2 3.0.CO;2-PCitations: 38AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract To clarify the role of glial fibrillary acidic protein (GFAP)-expressed glial cells in the circadian clock, we examined GFAP expression in the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) under various lighting conditions in mice. We demonstrated that GFAP expression did not show daily change in the SCN under a light-dark cycle; however, long-term housing under constant lighting conditions led to dramatic changes in GFAP expression, i.e., a decrease in the SCN and an increase in the IGL. Furthermore, mice that had a targeted deletion in the GFAP gene (GFAP mutant mice) showed longer and more arrhythmic circadian activity rhythms in constant lighting conditions than wild-type mice, while GFAP mutant mice exhibited stable circadian rhythms both in a light-dark cycle and constant darkness, and showed normal entrainment to environmental light stimuli. These results suggest that the GFAP-expressed astroglial cells in the SCN and the IGL may have some role in circadian oscillation under constant lighting conditions. J. Neurosci. Res. 60:212–218, 2000 © 2000 Wiley-Liss, Inc. Citing Literature Volume60, Issue215 April 2000Pages 212-218 RelatedInformation
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