Nitrogen-Assisted Ortho Lithiation: One-Pot Synthesis of New Classes of Bidentate and Tetradentate Mixed P∼N Ligands
2006; American Chemical Society; Volume: 25; Issue: 12 Linguagem: Inglês
10.1021/om060208e
ISSN1520-6041
AutoresLeïla Boubekeur‐Lecaque, Louis Ricard, Nicolas Mézailles, Matthieu Demange, Audrey Auffrant, Pascal Le Floch,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoMetalation of one aryl group of Ph3PNR (R = methyl, isopropyl) affords an easy access to the corresponding lithium salt, which in turn reacts with chlorophosphines R2PCl (R = Ph, i-Pr) to yield a new class of bidentate ligand featuring one iminophosphorane and one phosphino group. Reaction of the phenyl derivative with [Pd(COD)Cl2] yielded the expected six-membered palladacycle complex, which was structurally characterized. Extension of this new synthetic methodology toward the elaboration of enantiomerically pure tetradentate ligands has also been achieved.
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