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BIBTEX RIS

Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua

2002; Brazilian Society of Genetics; Volume: 25; Issue: 1 Linguagem: Inglês

10.1590/s1415-47572002000100005

ISSN

1678-4685

Autores

Nancy Moreno, José Antônio Baddini Martínez, Zorella Blanco, Leidys Osorio, Patrick Hackshaw,

Tópico(s)

Forensic and Genetic Research

Resumo

Seven polymorphic sites in the beta-globin gene cluster were analyzed on a sample of 96 chromosomes of Venezuelan sickle cell patients from the State of Aragua. The Benin haplotype was predominant with a frequency of 0.479, followed by the Bantu haplotype (0.406); a minority of cases with other haplotypes was also identified: atypical Bantu A2 (0.042), Senegal (0.031), atypical Bantu A7 (0.021) and Saudi Arabia/Indian (0.021) haplotypes; however, the Cameroon haplotype was not identified in this study. Our results are in agreement with the historical records that establish Sudanese and Bantu origins for the African slaves brought into Venezuela.

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