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Clinical and biological features of acute promyelocytic leukemia patients developing retinoic acid syndrome during induction treatment with all-trans retinoic acid and idarubicin

2008; Ferrata Storti Foundation; Volume: 93; Issue: 12 Linguagem: Inglês

10.3324/haematol.13510

1592-8721

M. Breccia, Roberto Latagliata, Ida Carmosino, Laura Cannella, Daniela Diverio, Anna Guarini, M. S. De Propris, Maria Concetta Petti, Giuseppe Avvisati, Giuseppe Cimino, F Mandelli, Francesco Lo‐Coco,

Drug-Induced Ocular Toxicity

hemoglobin level were not significant predictors of ACS events.The rate of pain was not increased in those with asthma diagnosis (0.72 events per patient year for those with asthma and 0.60 events per patient year for those without asthma, p value=0.53).Furthermore, baseline white blood cell count, percent fetal hemoglobin and baseline hemoglobin were not significant predictors of pain episodes (Table 2).When compared to the remaining group of children without asthma (n=280), children taking daily inhaled corticosteroids (n=17) had an increased rate of ACS (0.43 events per patient-year vs. 0.16 events per patient-year; p-value=0.002)and no significant increase in rate of pain (0.99 events per patientyear vs. 0.59 events per patient-year; p=0.122) .Evidence from previous studies suggested that asthma is associated with increased rates of ACS events 2,3,4 and pain episodes. 2 The results of this study confirmed previous data indicating an association between asthma and ACS events, but did not reveal an association between asthma and pain events.The reasons for the lack of association between asthma and pain in the Créteil population are not known, but may be related to differences in how care is delivered in that center and/or unmeasured environmental factors.Two studies have assessed the impact of the environment on SCD-related pain episodes. 5,6 Both studies demonstrated that local environmental factors may contribute to the rate of hospitalization for pain. 5,6 The background rate of asthma among the children with SCA in France, 8.4%, was not significantly different from a comparable cohort of children of African descent living in France, 9.1%. 7 Taken together, these studies provide no evidence that a physician diagnosis of asthma occurs more frequently among children with sickle cell disease when compared to children without sickle cell anemia.In summary, we provide further support that asthma is a potentially treatable risk factor associated with ACS.Future prospective studies to classify lung disease associated with SCA and to determine the effectiveness of asthma management in preventing SCA-related morbidity are warranted.