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Discordant xenografting: challenges and controversies

1991; Elsevier BV; Volume: 3; Issue: 5 Linguagem: Inglês

10.1016/0952-7915(91)90105-a

1879-0372

Jeffrey L. Platt, Fritz H. Bach,

Organ Donation and Transplantation

The transplantation of organs between individuals of disparate species is being considered as a potential solution to a serious shortage of donor organs for clinical transplantation. We summarize recent papers concerning the immunologic barrier to xenotransplantation, the pathogenesis of hyperacute rejection and reports on efforts made to prevent or mitigate hyperacute xenograft rejection.