Constraints on the Structure of (CUG) 97 RNA from Magic‐Angle‐Spinning Solid‐State NMR Spectroscopy
2006; Wiley; Volume: 45; Issue: 34 Linguagem: Inglês
10.1002/anie.200600769
ISSN1521-3773
AutoresKerstin Riedel, Christian T. Herbst, Sabine Häfner, Jörg Leppert, Oliver Ohlenschläger, Maurice S. Swanson, Matthias Görlach, Ramadurai Ramachandran,
Tópico(s)RNA modifications and cancer
ResumoAngewandte Chemie International EditionVolume 45, Issue 34 p. 5620-5623 Communication Constraints on the Structure of (CUG)97 RNA from Magic-Angle-Spinning Solid-State NMR Spectroscopy† Kerstin Riedel, Kerstin Riedel Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorChristian Herbst, Christian Herbst Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorSabine Häfner, Sabine Häfner Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorJörg Leppert Dr., Jörg Leppert Dr. Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorOliver Ohlenschläger Dr., Oliver Ohlenschläger Dr. Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorMaurice S. Swanson Prof. Dr., Maurice S. Swanson Prof. Dr. Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0266, USASearch for more papers by this authorMatthias Görlach Dr., Matthias Görlach Dr. Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorRamadurai Ramachandran Dr., Ramadurai Ramachandran Dr. raman@fli-leibniz.de Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this author Kerstin Riedel, Kerstin Riedel Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorChristian Herbst, Christian Herbst Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorSabine Häfner, Sabine Häfner Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorJörg Leppert Dr., Jörg Leppert Dr. Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorOliver Ohlenschläger Dr., Oliver Ohlenschläger Dr. Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorMaurice S. Swanson Prof. Dr., Maurice S. Swanson Prof. Dr. Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0266, USASearch for more papers by this authorMatthias Görlach Dr., Matthias Görlach Dr. Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this authorRamadurai Ramachandran Dr., Ramadurai Ramachandran Dr. raman@fli-leibniz.de Research Group Molecular Biophysics/NMR Spectroscopy, Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany, Fax: (+49) 3641-656-225Search for more papers by this author First published: 21 August 2006 https://doi.org/10.1002/anie.200600769Citations: 24 † This study has been funded in part by a PhD fellowship to Kerstin Riedel from the Stiftung Stipendien-Fonds des Verbandes der Chemischen Industrie e.V. and a grant from the Deutsche Forschungsgemeinschaft (grant no.: GO474/6-1). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Twists in a spin: RNA structural constraints have been obtained directly by exploiting the dependence of inter- and intranucleotide 1H–1H interactions on RNA conformation through the use of 13C MAS solid-state NMR spectroscopy. The data provide evidence that (CUG)97 RNA principally adopts an A-form helix conformation with a C3′-endo sugar pucker and an anti glycosidic torsion angle χ (see model). Citing Literature Volume45, Issue34August 25, 2006Pages 5620-5623 RelatedInformation
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