Portal de Periódicos da CAPES

Kinesin-5 acts as a brake in anaphase spindle elongation

2007; Elsevier BV; Volume: 17; Issue: 12 Linguagem: Inglês

10.1016/j.cub.2007.05.001

1879-0445

Adam M. Saunders, James Powers, Susan Strome, William M. Saxton,

Cellular Mechanics and Interactions

Bipolar kinesin-5 motors, essential in diverse organisms, can generate positive sliding forces between overlapped interpolar microtubules to push mitotic spindle poles apart. BMK-1, the sole Caenorhabditis elegans kinesin-5, is not essential. We have determined, by tracking pole movements in bmk-1 mutant C. elegans embryos, that BMK-1 actually resists pole separation during anaphase. This provides in vivo evidence that kinesin-5, when challenged by fast pole separation forces, can serve as a rate-limiting brake for interpolar microtubule sliding.