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Alternative splicing of CD79a ( ) and CD79b ( ) RNA transcripts in human B cells

1995; Elsevier BV; Volume: 32; Issue: 9 Linguagem: Inglês

10.1016/0161-5890(95)00023-8

1872-9142

Shiori Hashimoto, Nicholas Chiorazzi, Peter K. Gregersen,

T-cell and B-cell Immunology

The CD79a (Ig-αmb-1) and CD79b (Ig-βB29) molecules form a membrane heterodimer that is non-covalently associated with surface membrane immunoglobulin and is the major signaling component of the B cell antigen receptor complex. We have defined variant RNA transcripts for both CD79a (Ig-αmb-1) and CD79b (Ig-βB29) which appear to arise by alternative splicing. These splice variants are predicted to encode truncated forms of these molecules that result in the deletion of the entire extracellular Ig-like domain of CD79b and of a major portion of the extracellular domain of CD79a. The presence of these short transcripts in a variety of human B cells and B cell lines was established by an RNAse protection assay. The definition of these variant transcripts provides a basis for a continuing effort to define variant protein products of CD79a and CD79b and examine their role in B cell physiology.