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Synergistic Interplay of a Non‐Heme Iron Catalyst and Amino Acid Coligands in H 2 O 2 Activation for Asymmetric Epoxidation of α‐Alkyl‐Substituted Styrenes

2015; Wiley; Volume: 54; Issue: 9 Linguagem: Inglês

10.1002/anie.201410557

1521-3773

Olaf Cussó, Xavi Ribas, Julio Lloret‐Fillol, Miguel Costas,

Synthesis and Catalytic Reactions

Abstract Highly enantioselective epoxidation of α‐substituted styrenes with aqueous H 2 O 2 is described by using a chiral iron complex as the catalyst and N‐protected amino acids (AAs) as coligands. The amino acids synergistically cooperate with the iron center in promoting an efficient activation of H 2 O 2 to catalyze epoxidation of this challenging class of substrates with good yields and stereoselectivities (up to 97 % ee ) in short reaction times.