Interference with S and G2 phase progression by polyamine synthesis inhibitors
1978; Elsevier BV; Volume: 111; Issue: 2 Linguagem: Inglês
10.1016/0014-4827(78)90192-1
ISSN1090-2422
AutoresOlle Heby, Gunnar Andersson, Joe W. Gray,
Tópico(s)Cancer Research and Treatments
ResumoThe distribution of Ehrlich ascites tumor cells in the cell cycle was studied by flow cytometry following treatment with α-methyl ornithine (αMO) or methylglyoxal-bis(guanylhydrazone) (MeGAG). αMO and MeGAG are potent inhibitors of ornithine decarboxylase (putrescine synthesis) and S-adenosyl-methionine decarboxylase (spermidine and spermine synthesis), respectively. The data show that these polyamine synthesis inhibitors produce significant cell cycle perturbations resulting in an accumulation of cells in S and G2. This fact suggests that a normal polyamine complement is essential for the progression through these phases of the cell cycle.
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