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Neurocognitive Sequelae of Pediatric Sickle Cell Disease: A Review of the Literature

2007; Taylor & Francis; Volume: 13; Issue: 2 Linguagem: Inglês

10.1080/09297040600800956

1744-4136

Leslie Berkelhammer, Adrienne Williamson, Stacy D. Sanford, Courtney Dirksen, William G. Sharp, Allison S. Margulies, Rebecca A. Prengler,

Pharmacological Effects and Toxicity Studies

This literature review summarizes all studies relating neuropsychological performance to neuroimaging findings in pediatric sickle cell disease (N=28; published 1991–2005). Although inconsistencies exist within and across domains, deficits in intelligence (IQ), attention and executive functions, memory, language, visuomotor abilities, and academic achievement have been identified. Overall neurocognitive compromise was revealed to be related to the level of neurological injury and the location of silent infarct. Attentional and executive dysfunction is prevalent and related to frontal lobe abnormalities.