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Effects of prostaglandins F-2 and E-2 on cervical extensibility in the late pregnant rat

1980; Bioscientifica; Volume: 58; Issue: 1 Linguagem: Inglês

10.1530/jrf.0.0580095

1741-7899

Michael A. Hollingsworth, S. Gallimore, C. N. M. Isherwood,

Preterm Birth and Chorioamnionitis

Summary. The extensibility of the cervix of rats was measured in vitro on Day 19 of pregnancy and was doubled after 2 s.c. injections of PGF-2α (1 mg/kg) or PGE-2 (5 mg/kg) on Day 18. Progesterone (10 mg/kg) given on Day 18 had no effect alone or on the effect of PGE-2 but abolished the action of PGF-2α. PGE-2, but not PGF-2α, increased extensibility when given on Day 18 to rats which had been bilaterally ovariectomized on Day 16 and given oestradiol benzoate plus progesterone twice daily. High concentrations of PGF-2α or PGE-2 had no effect on the extensibility of Day-18 pregnant rat cervix in vitro. It is suggested that PGF-2α acts via the ovaries to decrease progesterone secretion and perhaps release relaxin, but PGE-2 would appear to have another site of action.