Lipase-catalyzed efficient kinetic resolution of 3-hydroxy-3-(pentafluorophenyl)propionitrile
1997; Elsevier BV; Volume: 38; Issue: 11 Linguagem: Inglês
10.1016/s0040-4039(97)00255-4
ISSN1873-3581
AutoresTakashi Sakai, Tatsuo Takayama, Takafumi Ohkawa, Osamu Yoshio, Tadashi Ema, Masanori Utaka,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoAbstract Efficient kinetic resolution of racemic 3-hydroxy-3-(pentafluorophenyl)- propionitrile (±)-1 by a lipase-catalyzed transesterification gave optically pure (S)-3-hydroxy-3-(pentafluorophenyl)-propionitrile (S)- 1 and (R)-(+)-3- acetoxy-3-(penta-fluorophenyl)propionitrile (R)- 1 [>99% ee, respectively, E = 1057], the former of which was further transformed into (S)-(−)-3-amino-1-(pentafluorophenyl)-1-propanol (S)- 7 in four steps.
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