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5-Fluorouracil in hepatocellular carcinoma.Report of twenty-one cases

1977; Wiley; Volume: 39; Issue: 5 Linguagem: Inglês

10.1002/1097-0142(197705)39

1097-0142

John S. Link, Joseph R. Bateman, Warren S. Paroly, W J Durkin, Robert L. Peters,

Multiple and Secondary Primary Cancers

CancerVolume 39, Issue 5 p. 1936-1939 ArticleFree Access 5-Fluorouracil in hepatocellular carcinoma. Report of twenty-one cases John S. Link MD, John S. Link MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Medicine, University of Southern California School of Medicine and Medical Oncology Division, L.A.C.-U.S.C.-M.C.Search for more papers by this authorJoseph R. Bateman MD, Joseph R. Bateman MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Pathology, University of Southern California School of Medicine and John Wesley County Hospital.Search for more papers by this authorWarren S. Paroly MD, Corresponding Author Warren S. Paroly MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Medicine, University of Southern California School of Medicine and Medical Oncology Division, L.A.C.-U.S.C.-M.C.Medical Oncology Division, LAC-USC-MC, 1200 N. State Street, Los Angeles, CA 90033===Search for more papers by this authorWalter J. Durkin MD, Walter J. Durkin MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Medicine, University of Southern California School of Medicine and Medical Oncology Division, L.A.C.-U.S.C.-M.C.Search for more papers by this authorRobert L. Peters MD, Robert L. Peters MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Pathology, University of Southern California School of Medicine and John Wesley County Hospital.Search for more papers by this author John S. Link MD, John S. Link MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Medicine, University of Southern California School of Medicine and Medical Oncology Division, L.A.C.-U.S.C.-M.C.Search for more papers by this authorJoseph R. Bateman MD, Joseph R. Bateman MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Pathology, University of Southern California School of Medicine and John Wesley County Hospital.Search for more papers by this authorWarren S. Paroly MD, Corresponding Author Warren S. Paroly MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Medicine, University of Southern California School of Medicine and Medical Oncology Division, L.A.C.-U.S.C.-M.C.Medical Oncology Division, LAC-USC-MC, 1200 N. State Street, Los Angeles, CA 90033===Search for more papers by this authorWalter J. Durkin MD, Walter J. Durkin MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Medicine, University of Southern California School of Medicine and Medical Oncology Division, L.A.C.-U.S.C.-M.C.Search for more papers by this authorRobert L. Peters MD, Robert L. Peters MD Medical Oncology Division, Los Angeles County-U.S.C. Medical Center, Los Angeles, Californi Department of Pathology, University of Southern California School of Medicine and John Wesley County Hospital.Search for more papers by this author First published: May 1977 https://doi.org/10.1002/1097-0142(197705)39:5 3.0.CO;2-NCitations: 43 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Twenty-one patients with biopsy-proven hepatocellular carcinoma were treated with oral or intravenous 5-Fluorouracil according to a ramdomized treatment schedule. Twenty-one patients were evaluable for response and toxicity. The two groups were comparable in distribution of pretreatment characteristics. There were no objective responses in either group. This is the largest reported group of patients with hepatocellular carcinoma treated with 5-Fluorouracil. Toxicity occurred in 46% of patients treated, but was tolerable. In contrast to previous reports,11,13 we have found that weekly 5-Fluorouracil given orally or intravenously is not of significant value in the treatment of hepatocellular carcinoma. References 1 Bateman, J. R., Pugh, R. P., Cassidy, F. R., Marshall, G. J., and Irwin, L. E.: 5-Fluorouracil given once weekly: Comparison of intravenous and oral administration. Cancer 28: 907–913, 1971. 10.1002/1097-0142(1971)28:4 3.0.CO;2-9 CASPubMedWeb of Science®Google Scholar 2 Davis, H., Guillermo, R., and Ansfield, F.: Adeno-carcinomas of stomach, pancreas, liver and biliary tracts. 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L., Afroudakis, A., and Tatter, D.: The changing incidence of association of hepatitis B with hepatocellular carcinoma in California. Submitted to Am. J. Clin. Pathol. Google Scholar 17 Ramirez, G., Ansfield, F., and Curreri, A.: Hepatoma: Long-term survival with desseminated tumor treated with 5-fluorouracil. Am. J. Surg. 120: 400–403, 1970. CASPubMedWeb of Science®Google Scholar Citing Literature Volume39, Issue5May 1977Pages 1936-1939 ReferencesRelatedInformation