Use of T2-weighted susceptibility contrast MRI for mapping the blood volume in the glioma-bearing rat brain
1999; Wiley; Volume: 42; Issue: 4 Linguagem: Inglês
10.1002/(sici)1522-2594(199910)42
ISSN1522-2594
AutoresG�raldine Le Duc, Michel P�oc'h, Chantal R�my, Odile Charpy, Robert N. Müller, Jean Fran�ois Le Bas, Michel D�corps,
Tópico(s)Advanced Neuroimaging Techniques and Applications
ResumoThe aim of this work was to evaluate the potential of T2-weighted, steady-state susceptibility-enhanced contrast magnetic resonance imaging (MRI), to characterize brain tumor heterogeneity and tumor vascularization. In vivo T2-weighted MRI experiments were carried out on normal rats (n = 11) and rats bearing C6 glioma (n = 17), before and after the injection of a remanent superparamagnetic contrast agent. The ΔR2 variations of the transverse relaxation rate due to the injection of the contrast agent were used to generate relative cerebral blood volume (CBV) maps. Contrast enhancement of the tumor was shown to reflect tissue vascularization rather than leakage of the blood-brain barrier. The quantitative results clearly show the heterogeneity of tumor vascularization and reveal a high vessel density in the peripheral area (CBVper ∝ 17.2 ± 2.3 sec−1) and a low vessel density in the central area of the tumor (CBVcen ∝ 2.5 ± 0.5 sec−1). Magn Reson Med 42:754–761, 1999. © 1999 Wiley-Liss, Inc.
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