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LINGO1 rs9652490 is associated with essential tremor and Parkinson disease

2009; Elsevier BV; Volume: 16; Issue: 2 Linguagem: Inglês

10.1016/j.parkreldis.2009.08.006

1873-5126

Carles Vilariño‐Güell, Owen A. Ross, Christian Wider, Barbara Jasińska‐Myga, Stephanie A. Cobb, Alexandra I. Soto‐Ortolaza, Jennifer M. Kachergus, Brett H. Keeling, Justus C. Dächsel, Heather L. Melrose, Bahareh Behrouz, Zbigniew K. Wszołek, Ryan J. Uitti, Jan Aasly, Alex Rajput, Matthew J. Farrer,

Parkinson's Disease Mechanisms and Treatments

Recently, a variant in LINGO1 (rs9652490) was found to associate with increased risk of essential tremor. We set out to replicate this association in an independent case-control series of essential tremor from North America. In addition, given the clinical and pathological overlap between essential tremor and Parkinson disease, we also evaluate the effect of LINGO1 rs9652490 in two case-control series of Parkinson disease. Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.