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Molecular Characterization of 125 I Decay and X-ray-induced HPRT Mutants in CHO Cells

1987; Taylor & Francis; Volume: 51; Issue: 2 Linguagem: Inglês

10.1080/09553008714550691

0020-7616

Richard A. Gibbs, James Camakaris, G. S. Hodgson, Roger F. Martin,

Trypanosoma species research and implications

SummaryThe predominant initial lesion induced by 125I decay in DNA is a double-strand DNA break comprising a ‘mini deletion’ of up to several base pairs (bp). However, Southern analysis of the structure of 125I decay-induced HPRT mutants in Chinese hamster ovary cells revealed that most of the mutants are deletions of thousands of bps. A similar predominance of substantial deletions was also found in X-ray-induced mutants.KeywordsmutagenesisHPRT locus125I decay