Portal de Periódicos da CAPES

Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

2011; Wiley; Volume: 50; Issue: 27 Linguagem: Inglês

10.1002/anie.201101804

1521-3773

Nina Svensen, Juan J. Díaz‐Mochón, Kevin Dhaliwal, Songsak Planonth, Michael Dewar, J. Douglas Armstrong, Mark Bradley,

Chemical Synthesis and Analysis

Angewandte Chemie International EditionVolume 50, Issue 27 p. 6133-6136 Communication Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery† Dr. Nina Svensen, Dr. Nina Svensen School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453Search for more papers by this authorDr. Juan José Díaz-Mochón, Dr. Juan José Díaz-Mochón School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453Search for more papers by this authorDr. Kevin Dhaliwal, Dr. Kevin Dhaliwal MRC Centre for Inflammation Research, The University of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA (UK)Search for more papers by this authorSongsak Planonth, Songsak Planonth School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453Search for more papers by this authorDr. Michael Dewar, Dr. Michael Dewar School of Informatics, The University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB (UK)Search for more papers by this authorDr. J. Douglas Armstrong, Dr. J. Douglas Armstrong School of Informatics, The University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB (UK)Search for more papers by this authorProf. Mark Bradley, Corresponding Author Prof. Mark Bradley mark.bradley@ed.ac.uk School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453Search for more papers by this author Dr. Nina Svensen, Dr. Nina Svensen School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453Search for more papers by this authorDr. Juan José Díaz-Mochón, Dr. Juan José Díaz-Mochón School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453Search for more papers by this authorDr. Kevin Dhaliwal, Dr. Kevin Dhaliwal MRC Centre for Inflammation Research, The University of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA (UK)Search for more papers by this authorSongsak Planonth, Songsak Planonth School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453Search for more papers by this authorDr. Michael Dewar, Dr. Michael Dewar School of Informatics, The University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB (UK)Search for more papers by this authorDr. J. Douglas Armstrong, Dr. J. Douglas Armstrong School of Informatics, The University of Edinburgh, 10 Crichton Street, Edinburgh, EH8 9AB (UK)Search for more papers by this authorProf. Mark Bradley, Corresponding Author Prof. Mark Bradley mark.bradley@ed.ac.uk School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453School of Chemistry, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ (UK), Fax: (+44) 131-650-6453Search for more papers by this author First published: 21 June 2011 https://doi.org/10.1002/anie.201101804Citations: 27 † We thank the EPSRC and BBSRC for funding. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract To the point: The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell-selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)-encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201101804_sm_miscellaneous_information.pdf3.8 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume50, Issue27June 27, 2011Pages 6133-6136 RelatedInformation