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The suicide brain: a review of postmortem receptor/transporter binding studies

1998; Elsevier BV; Volume: 22; Issue: 5 Linguagem: Inglês

10.1016/s0149-7634(97)00061-4

1873-7528

Ruth Gross‐Isseroff,

Ion channel regulation and function

GROSS-ISSEROFF, R., A. BIEGON, H. VOET AND A. WEIZMAN. The suicide brain: a review of postmortem receptor/transporter binding studies. NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, 199?. — The present review summarizes the last 15 years of research involving postmortem receptor/transporter binding studies on brains of suicide victims. It is our working hypothesis, on the basis of psychological, behavioral and epidemiological studies, that suicidal behavior is an independent unique behavioral entity with specific neurochemical characteristics. This review tries to test this hypothesis at the level of neurotransmitter receptors by using a different approach to data analysis. We suggest that this statistical approach, involving multivariate analyses, can contribute to the formulation of new hypotheses at the level of molecular biology and genetics. Such studies if undertaken in the future, would help define suicidal behavior as a psycho-neuro-pathological entity.