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BIBTEX RIS

Tubular variant of basal cell adenoma shares immunophenotypical features with normal intercalated ducts and is closely related to intercalated duct lesions of salivary gland

2013; Wiley; Volume: 64; Issue: 6 Linguagem: Inglês

10.1111/his.12339

1365-2559

Victor Ângelo Martins Montalli, Elizabeth Ferreira Martinez, Álfio José Tincani, Antônio Santos Martins, Maria do Carmo Abreu, Catarina Neves, Ana Flávia Costa, Vera Cavalcanti de Araújo, Albina Altemani,

Oral and Maxillofacial Pathology

Aims The morphological criteria for identification of intercalated duct lesions ( IDL s) of salivary glands have been defined recently. It has been hypothesised that IDL could be a precursor of basal cell adenoma ( BCA ). BCA s show a variety of histological patterns, and the tubular variant is the one that presents the strongest resemblance with IDL s. The aim of this study was to analyse the morphological and immunohistochemical profiles of IDL s and BCA s classified into tubular and non‐tubular subtypes, to determine whether or not IDL and tubular BCA represent distinct entities. Methods and results Eight IDL s, nine tubular BCA s and 19 non‐tubular BCA s were studied. All tubular BCA s contained IDL ‐like areas, which represented 20–70% of the tumour. In non‐tubular BCA , IDL ‐like areas were occasional and small (<5%). One patient presented IDL s, tubular BCA s and IDL /tubular BCA combined lesions. Luminal ductal cells of IDL s and tubular BCA s exhibited positivity for CK 7, lysozyme, S100 and DOG 1. In the non‐tubular BCA group, few luminal cells exhibited such an immunoprofile; they were mainly CK 14‐positive. Basal/myoepithelial cells of IDL s, tubular BCA s and non‐tubular BCA s were positive for CK 14, calponin, α‐ SMA and p63; they were more numerous in BCA lesions. Conclusions IDL , tubular BCA and non‐tubular BCA form a continuum of lesions in which IDL s are related closely to tubular BCA . In both, the immunoprofile of luminal and myoepithelial cells recapitulates the normal intercalated duct. The difference between the adenoma‐like subset of IDL s and tubular BCA rests mainly on the larger numbers of myoepithelial cells in the latter. Our findings indicate that at least some BCA s can arise via IDL s.