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Relaxant Effects of the Essential Oil of Eucalyptus tereticornis and its Main Constituent 1,8-Cineole on Guinea-Pig Tracheal Smooth Muscle

2005; Thieme Medical Publishers (Germany); Volume: 71; Issue: 12 Linguagem: Inglês

10.1055/s-2005-873173

1439-0221

Lívia Noronha Coelho-de-Souza, José Henrique Leal‐Cardoso, Francisco José de Abreu Matos, Saad Lahlou, Pedro Jorge Caldas Magalhães,

Traditional Chinese Medicine Analysis

The effects of the essential oil of Eucalyptus tereticornis Sm. (EOET) on guinea-pig tracheal smooth muscle were investigated. EOET (10 - 1000 μg/mL) relaxed the tracheal basal tonus with an EC50 value of 125.3 [52.2 - 300.9] μg/mL. Its maximal relaxation (40 ± 6 %) was significantly lower than that evoked by aminophylline (209 ± 34 %). The K+-(60 mM)-induced contractions were significantly reduced by both EOET (200 - 1000 μg/mL) and its main constituent 1,8-cineole (600 - 1000 μg/mL). Acetylcholine (1 μM)-induced contractions were significantly enhanced by 1,8-cineole (10 - 1000 μg/mL). However, they were significantly enhanced and reduced by lower (200 - 400 μg/mL) and higher (800 - 1000 μg/mL) concentrations of EOET, respectively. Electrical field stimulation-induced contractions were significantly increased by EOET (100 - 600 μg/mL). In conclusion, EOET produces myorelaxant effects on guinea-pig isolated trachea, an effect that seems to result from a complex interaction between its monoterpenoid constituents.