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Interaction of yttrium compounds with serum and serum constituents in vitro

1958; Elsevier BV; Volume: 78; Issue: 1 Linguagem: Inglês

10.1016/0003-9861(58)90308-4

1096-0384

Betty Rosoff, Ruth Lewin, Hiram E. Hart, Grady L. Williams, Dániel László,

Pesticide Residue Analysis and Safety

A simple method for determining the relative metal-binding strength of chelating agents in physiological media has been proposed and the nature of yttrium chelate interaction with serum has been studied. Filterability of yttrium from serum and serum filtrate was found to be related to the stability (log K1) of the yttrium chelate. The pressure filtration data correspond also with animal and human excretion data obtained in our laboratory. The experiments with serum filtrate show that the diffusible serum components play a role in these yttrium interactions. The yttrium interaction with an isolated serum protein, albumin, was studied by the method of equilibrium dialysis. The moles of yttrium bound per mole of albumin increased as the metal-ion concentration was increased and the binding was found to be reversible, indicating that this is a multiple equilibrium reaction. The yttrium-albumin binding was affected by changes in pH and temperature.