Guanidine bridged nucleic acid (GuNA): an effect of a cationic bridged nucleic acid on DNA binding affinity
2013; Royal Society of Chemistry; Volume: 50; Issue: 5 Linguagem: Inglês
10.1039/c3cc46017g
ISSN1364-548X
AutoresAjaya R. Shrestha, Yutaro Kotobuki, Yoshiyuki Hari, Satoshi Obika,
Tópico(s)RNA Interference and Gene Delivery
ResumoA novel 2',4'-BNA/LNA analog bridged by guanidine, termed as guanidine bridged nucleic acid (GuNA), was synthesized and incorporated into oligonucleotides. Thermal stabilities and nuclease resistance of GuNA-modified oligonucleotides were investigated and compared with those of 2',4'-BNA/LNA and natural DNA oligonucleotides. GuNA exhibited interestingly high binding affinity towards complementary ssDNA than 2',4'-BNA/LNA.
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