Cerebral decortication reverses the effect of amphetamine on striatal D2 dopamine binding site density
1986; Elsevier BV; Volume: 72; Issue: 3 Linguagem: Inglês
10.1016/0304-3940(86)90535-5
ISSN1872-7972
Autores Tópico(s)Neuroscience and Neuropharmacology Research
ResumoUnilateral ablation of the cerebral cortex produces a decrease of approximately 38% in striatal D2 dopamine binding site density. Chronic d-amphetamine treatment also produces a decrease of about 22% in D2 binding site density. Paradoxically, when rats were hemidecorticated and treated chronically with d-amphetamine, the density of striatal D2 dopamine binding sites on the decorticated side was increased (by about 50%) rather than decreased. Evidently d-amphetamine-induced down-regulation of D2 dopamine binding sites depends on an intact corticostriatal pathway.
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