DIVISION OF BIOCHEMISTRY : A BIOCHEMICAL APPROACH TO CHEMOTHERAPY*
1961; Wiley; Volume: 23; Issue: 8 Series II Linguagem: Inglês
10.1111/j.2164-0947.1961.tb01404.x
ISSN2164-0947
Autores Tópico(s)Chemical Reactions and Isotopes
ResumoTransactions of the New York Academy of SciencesVolume 23, Issue 8 Series II p. 700-708 DIVISION OF BIOCHEMISTRY: A BIOCHEMICAL APPROACH TO CHEMOTHERAPY* George H. Hitchings, George H. Hitchings Wellcome Research Laboratories, Burroughs-Wellcome and Company, Inc., Tuckahoe, N. Y.Search for more papers by this author George H. Hitchings, George H. Hitchings Wellcome Research Laboratories, Burroughs-Wellcome and Company, Inc., Tuckahoe, N. Y.Search for more papers by this author First published: June 1961 https://doi.org/10.1111/j.2164-0947.1961.tb01404.xCitations: 11 † This paper, illustrated with slides, was presented at a meeting of the Division on May 23, 1961. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Hitchings, G. H., G. B. Elion, E. A. Falco, P. B. Russell, M. B. Sherwood & H. VanderWerff. 1950. Antagonists of nucleic acid derivatives. 1. The Lactobacillus casei model. J. Biol. Chem. 183: 1. 2 Hitchings, G. H., G. B. Elion, E. A. Falco, P. B. Russell & Vander Werff. 1950. Studies on analogs of purines and pyrimidines. Ann. N.Y. Acad. Sci. 52: 1318. 3 Hitchings, G. H. & G. B. Elion. 1954. The chemistry and biochemistry of purine analogs. Ann. N.Y. Acad. Sci. 60 (2): 195. 4 Hitchings, G. H. & G. B. Elion. 1956. Chemistry and Biochemistry of Antimetabolites Related to the Purines. In Proc. Third Internat. Congress Biochem., Brussels, 1955: 55– 61. Academic Press, Inc., New York. 5 Hitchings, G. H. 1958. Special microbiological systems. III. The use of lactic acid bacteria for the evaluation of purine and pyrimidine antagonists. Ann. N.Y. Acad. Sci. 76 (3): 490. 6 Hitchings, G. H., G. B. Elion, H. VanderWerff & E. A. Falco. 1948. Pyrimidine derivatives as antagonists of pteroylglutamic acid. J. Biol. Chem. 174: 765. 7 Hitchings, G. H., E. A. Falco, A. VanderWerff, P. B. Russel & G. B. Elion. 1952. Antagonists of nucleic acid derivatives. VII. 2,4-Diaminopyrimidines. J. Biol. Chem. 199: 43. 8 Rabinowitz, J. C. & R. H. Hines. 1960. Folic acid coenzymes. Federation Proc. 19: 963. 9 Huennekens, F. M., H. R. Whiteley & M. J. Osborn. 1959. Mechanisms of formylation and hydroxymethylation reactions. J. Cellular Comp. Physiol 54 (Suppl. 1): 109. 10 Larrabee, A. R. & J. M. Buchanan. 1961. A new intermediate of methionine synthesis. Federation Proc. 20: 9. 11 Werkheiser, W. C. 1961. Specific binding of 4-amino folic acid analogues by folic acid reductase. J. Biol. Chem. 236: 888. 12 Murphy, M. L., R. R. Ellison, D. A. Karnofsky & J. H. Burchenal. 1954. Clinical effects of the dichloro and monochlorophenyl analogues of diamino pyrimidine: Antagonists of folic acid. J. Clin. Invest 33: 1388. 13 Wood, R. C., R. Ferone & G. H. Hitchings. 1961. The relationship of cellular permeability to the degree of inhibition by amethopterin and pyrimethamine in several species of bacteria. Biochem. Pharmacol 6: 113. 14 Loebeck, M. E. 1960. Prevention of amethopterin inhibition by 2-methyladenine. J. Bacteriol 79: 384. 15 Pine, M. J. 1960. Uptake of aminopterin by Bacillus subtilis. J. Bacteriol 79: 827. 16 Pine, M. J. 1960. Reversal of aminopterin inhibition in Bacillus subtilis at the site of drug entry. J. Bacteriol 79: 835. 17 Frenkel, J. K. & G. H. Hitchings. 1957. Relative reversal by vitamins (p-aminobenzoic, folic, and folinic acids) of the effects of sulfadiazine and pyrimethamine on toxoplasma, mouse and man. Antibiotics & Chemotherapy, 7: 630. 18 Hitchings, G. H. 1960. Pyrimethamine. The use of an antimetabolite in the chemotherapy of malaria and other infections. Clin. Pharmacol. Therap 1: 570. 19 Elion, G. B., S. Singer & G. H. Hitchings. 1954. Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites. J. Biol. Chem. 208: 477. 20 Elion, G. B., S. Singer & G. H. Hitchings. 1960. Potentiation in combinations of three biochemically related antimetabolites. Antibiotics & Chemotherapy, 10: 556. 21 Elion, G. B., G. H. Hitchings, M. B. Sherwood & H. VanderWerff. 1950. Folic acid-like activity from xanthopterin. Arch. Biochem 26: 337. 22 Shiota, T. 1959. Enzymic synthesis of folic acid-like compounds by cellfree extracts of Lactobacillus arabinosus. Arch. Biochem. Biophys 80: 155. 23 Misra, D. K., S. R. Humphreys, M. Friedkin, A. Goldin & E. J. Crawford. 1961. Increased dihydrofolate reductase activity as a possible basis of drug resistance in leukemia. Nature 189: 39. Citing Literature Volume23, Issue8 Series IIJune 1961Pages 700-708 ReferencesRelatedInformation
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