Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea
1992; Royal Society; Volume: 249; Issue: 1325 Linguagem: Inglês
10.1098/rspb.1992.0102
ISSN1471-2954
AutoresCorné J. Kros, A. Rüsch, Guy P. Richardson,
Tópico(s)Hearing Loss and Rehabilitation
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Kros C. J. , Rusch A. and Richardson Guy Peel 1992Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochleaProc. R. Soc. Lond. B.249185–193http://doi.org/10.1098/rspb.1992.0102SectionRestricted accessArticleMechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea C. J. Kros Google Scholar Find this author on PubMed Search for more papers by this author , A. Rusch Google Scholar Find this author on PubMed Search for more papers by this author and Guy Peel Richardson Google Scholar Find this author on PubMed Search for more papers by this author C. J. Kros Google Scholar Find this author on PubMed , A. Rusch Google Scholar Find this author on PubMed and Guy Peel Richardson Google Scholar Find this author on PubMed Published:22 August 1992https://doi.org/10.1098/rspb.1992.0102AbstractThe first step towards the generation of the receptor potential in hair cells is the gating of the transducer channels and subsequent flow of transducer current, induced by deflection of the stereocilia. We describe properties of the transducer current in outer hair cells of neonatal mice. Less extensive observations on inner hair cells suggest that their transducer currents have similar characteristics. The hair bundles were stimulated by force from a fluid jet. The transducer currents in outer hair cells are the largest found so far in any hair cell, with a chord conductance of up to 9.2 nS at – 84 mV. The transfer function suggests that the channel has at least two closed states and one open state. The permeabilities for sodium, potassium and caesium are similar, consistent with the channel being a fairly non-selective cation channel. At negative potentials the currents adapt in most cells, although never as completely as in hair cells of lower vertebrates. If the unit conductance of the transducer channel is similar to that of the turtle's auditory hair cells (100 pS), then there are about 90 channels per hair bundle, or one channel between every pair of adjacent stereocilia in neighbouring rows.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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Mattingly J, Zhan K, Hiss M, Harris M, Dodson E, Moberly A, Adunka O and Riggs W (2019) Intraoperative Electrocochleography in Patients With Menière's Disease Undergoing Endolymphatic Sac Decompression and Shunt Surgery, Otology & Neurotology, 10.1097/MAO.0000000000002345, 40:9, (1208-1216), Online publication date: 1-Oct-2019. Altoè A, Pulkki V and Verhulst S (2018) The effects of the activation of the inner-hair-cell basolateral K+ channels on auditory nerve responses, Hearing Research, 10.1016/j.heares.2018.03.029, 364, (68-80), Online publication date: 1-Jul-2018. Salt A and Hirose K (2018) Communication pathways to and from the inner ear and their contributions to drug delivery, Hearing Research, 10.1016/j.heares.2017.12.010, 362, (25-37), Online publication date: 1-May-2018. Lee S and Koike T (2018) Simulation of mechano-electrical transduction in the cochlea considering basilar membrane vibration and the ionic current of the inner hair cells TO THE EAR AND BACK AGAIN - ADVANCES IN AUDITORY BIOPHYSICS: Proceedings of the 13th Mechanics of Hearing Workshop, 10.1063/1.5038458, , (030005) Verhulst S, Altoè A and Vasilkov V (2018) Computational modeling of the human auditory periphery: Auditory-nerve responses, evoked potentials and hearing loss, Hearing Research, 10.1016/j.heares.2017.12.018, 360, (55-75), Online publication date: 1-Mar-2018. Lee M, Hackelberg S, Green K, Lunghamer K, Kurioka T, Loomis B, Swiderski D, Duncan R and Raphael Y (2017) Survival of human embryonic stem cells implanted in the guinea pig auditory epithelium, Scientific Reports, 10.1038/srep46058, 7:1, Online publication date: 1-Aug-2017. Corey D, Ó Maoiléidigh D and Ashmore J (2017) Mechanical Transduction Processes in the Hair Cell Understanding the Cochlea, 10.1007/978-3-319-52073-5_4, (75-111), . Kenyon E, Kirkwood N, Kitcher S, O'Reilly M, Derudas M, Cantillon D, Goodyear R, Secker A, Baxendale S, Bull J, Waddell S, Whitfield T, Ward S, Kros C and Richardson G (2017)(2017)(2017)(2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death, JCI Insight, 10.1172/jci.insight.96773, 2:24, Online publication date: 21-Dec-2017., Online publication date: 21-Dec-2017., Online publication date: 21-Dec-2017., Online publication date: 21-Dec-2017. Altoè A, Pulkki V and Verhulst S (2017) Model-based estimation of the frequency tuning of the inner-hair-cell stereocilia from neural tuning curves, The Journal of the Acoustical Society of America, 10.1121/1.4985193, 141:6, (4438-4451), Online publication date: 1-Jun-2017. Marcotti W, Corns L, Goodyear R, Rzadzinska A, Avraham K, Steel K, Richardson G and Kros C (2016) The acquisition of mechano‐electrical transducer current adaptation in auditory hair cells requires myosin VI, The Journal of Physiology, 10.1113/JP272220, 594:13, (3667-3681), Online publication date: 1-Jul-2016. Liu X, Koehler K, Mikosz A, Hashino E and Holt J (2016) Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells, Nature Communications, 10.1038/ncomms11508, 7:1, Online publication date: 1-Sep-2016. Sexton J, Desmonds T, Quick K, Taylor R, Abramowitz J, Forge A, Kros C, Birnbaumer L and Wood J (2016) The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing, Neuroscience Letters, 10.1016/j.neulet.2015.10.052, 610, (36-42), Online publication date: 1-Jan-2016. Beurg M, Goldring A, Ricci A and Fettiplace R (2016) Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cells, Proceedings of the National Academy of Sciences, 10.1073/pnas.1601067113, 113:24, (6767-6772), Online publication date: 14-Jun-2016. Corns L and Marcotti W (2016) Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells , Physiological Reports, 10.14814/phy2.12701, 4:3, (e12701), Online publication date: 1-Feb-2016. Huth M, Han K, Sotoudeh K, Hsieh Y, Effertz T, Vu A, Verhoeven S, Hsieh M, Greenhouse R, Cheng A and Ricci A (2015) Designer aminoglycosides prevent cochlear hair cell loss and hearing loss, Journal of Clinical Investigation, 10.1172/JCI77424, 125:2, (583-592), Online publication date: 2-Feb-2015. Prodanovic S, Gracewski S and Nam J (2015) Power Dissipation in the Subtectorial Space of the Mammalian Cochlea Is Modulated by Inner Hair Cell Stereocilia, Biophysical Journal, 10.1016/j.bpj.2014.12.027, 108:3, (479-488), Online publication date: 1-Feb-2015. Beurg M, Goldring A and Fettiplace R (2015) The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells, Journal of General Physiology, 10.1085/jgp.201511458, 146:3, (233-243), Online publication date: 1-Sep-2015. Michalski N and Petit C (2014) Genetics of auditory mechano-electrical transduction, Pflügers Archiv - European Journal of Physiology, 10.1007/s00424-014-1552-9, 467:1, (49-72), Online publication date: 1-Jan-2015. Eatock R (2014) Recording from Hair Cells Perspectives on Auditory Research, 10.1007/978-1-4614-9102-6_5, (79-94), . Pirih P, Sendin G and van Netten S (2014) Techniques for Studying Neuromast Function in Zebrafish Flow Sensing in Air and Water, 10.1007/978-3-642-41446-6_14, (335-370), . Forgues M, Koehn H, Dunnon A, Pulver S, Buchman C, Adunka O and Fitzpatrick D (2014) Distinguishing hair cell from neural potentials recorded at the round window, Journal of Neurophysiology, 10.1152/jn.00446.2013, 111:3, (580-593), Online publication date: 1-Feb-2014. Fettiplace R and Kim K (2014) The Physiology of Mechanoelectrical Transduction Channels in Hearing, Physiological Reviews, 10.1152/physrev.00038.2013, 94:3, (951-986), Online publication date: 1-Jul-2014. Ni G, Elliott S, Ayat M and Teal P (2014) Modelling Cochlear Mechanics, BioMed Research International, 10.1155/2014/150637, 2014, (1-42), . Yi L and David Z H (2014) The Cochlear Amplifier: Is it Hair Bundle Motion of Outer Hair Cells?, Journal of Otology, 10.1016/S1672-2930(14)50017-7, 9:2, (64-72), Online publication date: 1-Jun-2014. Corns L, Johnson S, Kros C and Marcotti W (2014) Calcium entry into stereocilia drives adaptation of the mechanoelectrical transducer current of mammalian cochlear hair cells, Proceedings of the National Academy of Sciences, 10.1073/pnas.1409920111, 111:41, (14918-14923), Online publication date: 14-Oct-2014. Beurg M, Tan X and Fettiplace R (2013) A Prestin Motor in Chicken Auditory Hair Cells: Active Force Generation in a Nonmammalian Species, Neuron, 10.1016/j.neuron.2013.05.018, 79:1, (69-81), Online publication date: 1-Jul-2013. Kim K and Fettiplace R (2012) Developmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel–like proteins, Journal of General Physiology, 10.1085/jgp.201210913, 141:1, (141-148), Online publication date: 1-Jan-2013. Dong W and Olson E (2013) Detection of Cochlear Amplification and Its Activation, Biophysical Journal, 10.1016/j.bpj.2013.06.049, 105:4, (1067-1078), Online publication date: 1-Aug-2013. Tan X, Beurg M, Hackney C, Mahendrasingam S and Fettiplace R (2013) Electrical tuning and transduction in short hair cells of the chicken auditory papilla, Journal of Neurophysiology, 10.1152/jn.01028.2012, 109:8, (2007-2020), Online publication date: 15-Apr-2013. Kim K, Beurg M, Hackney C, Furness D, Mahendrasingam S and Fettiplace R (2013) The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels, Journal of General Physiology, 10.1085/jgp.201311068, 142:5, (493-505), Online publication date: 1-Nov-2013. Quick K, Zhao J, Eijkelkamp N, Linley J, Rugiero F, Cox J, Raouf R, Gringhuis M, Sexton J, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros C, Richardson G, Freichel M, Flockerzi V, Birnbaumer L and Wood J (2012) TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells, Open Biology, 2:5, Online publication date: 1-May-2012. Pan B, Waguespack J, Schnee M, LeBlanc C and Ricci A (2012) Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structure, Journal of Neurophysiology, 10.1152/jn.01178.2011, 107:9, (2408-2420), Online publication date: 1-May-2012. Meaud J and Grosh K (2011) Coupling Active Hair Bundle Mechanics, Fast Adaptation, and Somatic Motility in a Cochlear Model, Biophysical Journal, 10.1016/j.bpj.2011.04.049, 100:11, (2576-2585), Online publication date: 1-Jun-2011. Peng A, Salles F, Pan B and Ricci A (2011) Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransduction, Nature Communications, 10.1038/ncomms1533, 2:1, Online publication date: 1-Sep-2011. Stepanyan R, Indzhykulian A, Vélez-Ortega A, Boger E, Steyger P, Friedman T and Frolenkov G (2011) TRPA1-Mediated Accumulation of Aminoglycosides in Mouse Cochlear Outer Hair Cells, Journal of the Association for Research in Otolaryngology, 10.1007/s10162-011-0288-x, 12:6, (729-740), Online publication date: 1-Dec-2011. Darbon P, Wright D and Evans M (2010) Conductance Properties of the Acetylcholine Receptor Current of Guinea Pig Outer Hair Cells, Journal of the Association for Research in Otolaryngology, 10.1007/s10162-010-0239-y, 12:1, (59-70), Online publication date: 1-Feb-2011. Johnson S, Beurg M, Marcotti W and Fettiplace R (2011) Prestin-Driven Cochlear Amplification Is Not Limited by the Outer Hair Cell Membrane Time Constant, Neuron, 10.1016/j.neuron.2011.04.024, 70:6, (1143-1154), Online publication date: 1-Jun-2011. Huth M, Ricci A and Cheng A (2011) Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection, International Journal of Otolaryngology, 10.1155/2011/937861, 2011, (1-19), . Shi–qin C, Ning Y, Sheng–nan Y, Shi–ming Y and Suo–qiang Z (2010) Measurement of Ca2+Flow in Cochlear Cells Using Non–Invasive Micro–Test Technique, Journal of Otology, 10.1016/S1672-2930(10)50019-9, 5:2, (90-96), Online publication date: 1-Dec-2010. McGee J and Walsh E (2010) Cochlear Transduction and the Molecular Basis of Auditory Pathology Cummings Otolaryngology - Head and Neck Surgery, 10.1016/B978-0-323-05283-2.00147-6, (2049-2085), . Kimitsuki T, Komune N, Noda T, Takaiwa K, Ohashi M and Komune S (2010) Property of IK,n in inner hair cells isolated from guinea-pig cochlea, Hearing Research, 10.1016/j.heares.2010.01.002, 261:1-2, (57-62), Online publication date: 1-Mar-2010. Ku E, Elliott S and Lineton B (2009) Limit cycle oscillations in a nonlinear state space model of the human cochlea, The Journal of the Acoustical Society of America, 10.1121/1.3158861, 126:2, (739-750), Online publication date: 1-Aug-2009. Petit C and Richardson G (2009) Linking genes underlying deafness to hair-bundle development and function, Nature Neuroscience, 10.1038/nn.2330, 12:6, (703-710), Online publication date: 1-Jun-2009. Abel C, Wittekindt A and Kössl M (2009) Contralateral Acoustic Stimulation Modulates Low-Frequency Biasing of DPOAE: Efferent Influence on Cochlear Amplifier Operating State?, Journal of Neurophysiology, 10.1152/jn.00026.2009, 101:5, (2362-2371), Online publication date: 1-May-2009. Salt A, Brown D, Hartsock J and Plontke S (2009) Displacements of the organ of Corti by gel injections into the cochlear apex, Hearing Research, 10.1016/j.heares.2009.02.001, 250:1-2, (63-75), Online publication date: 1-Apr-2009. Michalski N, Michel V, Caberlotto E, Lefèvre G, van Aken A, Tinevez J, Bizard E, Houbron C, Weil D, Hardelin J, Richardson G, Kros C, Martin P and Petit C (2009) Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells, Pflügers Archiv - European Journal of Physiology, 10.1007/s00424-009-0711-x, 459:1, (115-130), Online publication date: 1-Nov-2009. Gómez-Casati M, Wedemeyer C, Taranda J, Lipovsek M, Dalamon V, Elgoyhen A and Katz E (2009) Electrical Properties and Functional Expression of Ionic Channels in Cochlear Inner Hair Cells of Mice Lacking the α10 Nicotinic Cholinergic Receptor Subunit, Journal of the Association for Research in Otolaryngology, 10.1007/s10162-009-0164-0, 10:2, (221-232), Online publication date: 1-Jun-2009. Choung Y, Taura A, Pak K, Choi S, Masuda M and Ryan A (2009) Generation of highly-reactive oxygen species is closely related to hair cell damage in rat organ of corti treated with gentamicin, Neuroscience, 10.1016/j.neuroscience.2009.02.085, 161:1, (214-226), Online publication date: 1-Jun-2009. Martini M, Canella R, Fesce R and Rossi M (2008) Isolation and possible role of fast and slow potassium current components in hair cells dissociated from frog crista ampullaris, Pflügers Archiv - European Journal of Physiology, 10.1007/s00424-008-0598-y, 457:6, (1327-1342), Online publication date: 1-Apr-2009. Fettiplace R (2009) Defining features of the hair cell mechanoelectrical transducer channel, Pflügers Archiv - European Journal of Physiology, 10.1007/s00424-009-0683-x, 458:6, (1115-1123), Online publication date: 1-Oct-2009. Stauffer E, Lelli A and Holt J (2008) Hair Cell Transduction and Adaptation: Physiology and Molecular Mechanisms The Senses: A Comprehensive Reference, 10.1016/B978-012370880-9.00024-4, (263-292), . Russell I (2008) Cochlear Receptor Potentials The Senses: A Comprehensive Reference, 10.1016/B978-012370880-9.00030-X, (319-358), . Pickles J (2008) Physiology of hearing Scott-Brown's Otorhinolaryngology: Head and Neck Surgery 7Ed, 10.1201/b15118-252, (3173-3206), Online publication date: 25-Apr-2008. Kikuchi S, Ninomiya T, Kawamata T and Tatsumi H (2008) Expression of ASIC2 in ciliated cells and stereociliated cells, Cell and Tissue Research, 10.1007/s00441-008-0635-3, 333:2, (217-224), Online publication date: 1-Aug-2008. Oesterle E, Campbell S, Taylor R, Forge A and Hume C (2007) Sox2 and Jagged1 Expression in Normal and Drug-Damaged Adult Mouse Inner Ear, Journal of the Association for Research in Otolaryngology, 10.1007/s10162-007-0106-7, 9:1, (65-89), Online publication date: 1-Mar-2008. Van Aken A, Atiba-Davies M, Marcotti W, Goodyear R, Bryant J, Richardson G, Noben-Trauth K and Kros C (2008) TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice, The Journal of Physiology, 10.1113/jphysiol.2008.156992, 586:22, (5403-5418), Online publication date: 15-Nov-2008. Iwasa K and Sul B (2008) Effect of the cochlear microphonic on the limiting frequency of the mammalian ear, The Journal of the Acoustical Society of America, 10.1121/1.2953317, 124:3, (1607-1612), Online publication date: 1-Sep-2008. Ren T and Gillespie P (2007) A mechanism for active hearing, Current Opinion in Neurobiology, 10.1016/j.conb.2007.07.013, 17:4, (498-503), Online publication date: 1-Aug-2007. Stauffer E and Holt J (2007) Sensory Transduction and Adaptation in Inner and Outer Hair Cells of the Mouse Auditory System, Journal of Neurophysiology, 10.1152/jn.00914.2007, 98:6, (3360-3369), Online publication date: 1-Dec-2007. Grant L and Fuchs P (2007) Auditory transduction in the mouse, Pflügers Archiv - European Journal of Physiology, 10.1007/s00424-007-0253-z, 454:5, (793-804), Online publication date: 21-Jun-2007. Martin P Active Hair-Bundle Motility of the Hair Cells of Vestibular and Auditory Organs Active Processes and Otoacoustic Emissions in Hearing, 10.1007/978-0-387-71469-1_4, (93-143) Dinklo T, Meulenberg C and van Netten S (2007) Frequency-Dependent Properties of a Fluid Jet Stimulus: Calibration, Modeling, and Application to Cochlear Hair Cell Bundles, Journal for the Association for Research in Otolaryngology, 10.1007/s10162-007-0080-0, 8:2, (167-182), Online publication date: 1-Jun-2007. van Netten S and Kros C (2007) Insights into the Pore of the Hair Cell Transducer Channel from Experiments with Permeant Blockers Mechanosensitive Ion Channels, Part B, 10.1016/S1063-5823(06)59013-1, (375-398), . Ricci A and Kachar B (2007) Hair Cell Mechanotransduction: The Dynamic Interplay Between Structure and Function Mechanosensitive Ion Channels, Part B, 10.1016/S1063-5823(06)59012-X, (339-374), . Fettiplace R and Ricci A Mechanoelectrical Transduction in Auditory Hair Cells Vertebrate Hair Cells, 10.1007/0-387-31706-6_4, (154-203) Ricci A, Kachar B, Gale J and Van Netten S (2006) Mechano-electrical Transduction: New Insights into Old Ideas, The Journal of Membrane Biology, 10.1007/s00232-005-0834-8, 209:2-3, (71-88), Online publication date: 1-Jan-2006. Goodyear R, Kros C and Richardson G The Development of Hair Cells in the Inner Ear Vertebrate Hair Cells, 10.1007/0-387-31706-6_2, (20-94) Stepanyan R, Belyantseva I, Griffith A, Friedman T and Frolenkov G (2006) Auditory mechanotransduction in the absence of functional myosin-XVa, The Journal of Physiology, 10.1113/jphysiol.2006.118547, 576:3, (801-808), Online publication date: 1-Nov-2006. Marcotti W, Erven A, Johnson S, Steel K and Kros C (2006) Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea , The Journal of Physiology, 10.1113/jphysiol.2005.095661, 574:3, (677-698), Online publication date: 1-Aug-2006. Yorgason J, Fayad J and Kalinec F (2006) Understanding drug ototoxicity: molecular insights for prevention and clinical management, Expert Opinion on Drug Safety, 10.1517/14740338.5.3.383, 5:3, (383-399), Online publication date: 1-May-2006. KIMITSUKI T, MATSUDA K and KOMUNE S (2009) CALCIUM ACTION ON THE MEMBRANE CURRENTS POSSESSING THE PROPERTIES OF MECHANO-ELECTRIC TRANSDUCER CURRENTS IN INNER HAIR CELLS OF THE GUINEA-PIG COCHLEA, International Journal of Neuroscience, 10.1080/00207450500519689, 116:11, (1327-1335), Online publication date: 1-Jan-2006. Kössl M and Coro F (2006) L1,L2 maps of distortion-product otoacoustic emissions from a moth ear with only two auditory receptor neurons, The Journal of the Acoustical Society of America, 10.1121/1.2363934, 120:6, (3822-3831), Online publication date: 1-Dec-2006. Ugawa S, Inagaki A, Yamamura H, Ueda T, Ishida Y, Kajita K, Shimizu H and Shimada S (2006) Acid-sensing ion channel-1b in the stereocilia of mammalian cochlear hair cells, NeuroReport, 10.1097/01.wnr.0000233093.67289.66, 17:12, (1235-1239), Online publication date: 21-Aug-2006. Brownell W The Piezoelectric Outer Hair Cell Vertebrate Hair Cells, 10.1007/0-387-31706-6_7, (313-347) Lopez-Poveda E and Eustaquio-Martín A (2006) A Biophysical Model of the Inner Hair Cell: The Contribution of Potassium Currents to Peripheral Auditory Compression, Journal of the Association for Research in Otolaryngology, 10.1007/s10162-006-0037-8, 7:3, (218-235), Online publication date: 1-Sep-2006. Fettiplace R and Hackney C (2006) The sensory and motor roles of auditory hair cells, Nature Reviews Neuroscience, 10.1038/nrn1828, 7:1, (19-29), Online publication date: 1-Jan-2006. Fettiplace R (2006) Active hair bundle movements in auditory hair cells, The Journal of Physiology, 10.1113/jphysiol.2006.115949, 576:1, (29-36), Online publication date: 1-Oct-2006. Jia S and He D (2005) Motility-associated hair-bundle motion in mammalian outer hair cells, Nature Neuroscience, 10.1038/nn1509, 8:8, (1028-1034), Online publication date: 1-Aug-2005. Spector A, Popel A, Eatock R and Brownell W (2005) Mechanosensitive Channels in the Lateral Wall Can Enhance the Cochlear Outer Hair Cell Frequency Response, Annals of Biomedical Engineering, 10.1007/s10439-005-5749-0, 33:8, (991-1002), Online publication date: 1-Aug-2005. Michel V, Goodyear R, Weil D, Marcotti W, Perfettini I, Wolfrum U, Kros C, Richardson G and Petit C (2005) Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells, Developmental Biology, 10.1016/j.ydbio.2005.01.014, 280:2, (281-294), Online publication date: 1-Apr-2005. Staudacher E, Gebhardt M and Dürr V (2005) Antennal Movements and Mechanoreception: Neurobiology of Active Tactile Sensors Advances in Insect Physiology Volume 32, 10.1016/S0065-2806(05)32002-9, (49-205), . Kennedy H, Crawford A and Fettiplace R (2005) Force generation by mammalian hair bundles supports a role in cochlear amplification, Nature, 10.1038/nature03367, 433:7028, (880-883), Online publication date: 1-Feb-2005. Marcotti W, Van Netten S and Kros C (2005) The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano -electrical transducer channels, The Journal of Physiology, 10.1113/jphysiol.2005.085951, 567:2, (505-521), Online publication date: 1-Sep-2005. Meyer J, Preyer S, Hofmann S and Gummer A (2005) Tonic mechanosensitivity of outer hair cells after loss of tip links, Hearing Research, 10.1016/j.heares.2004.11.013, 202:1-2, (97-113), Online publication date: 1-Apr-2005. Coombs S and Van Netten S (2005) The Hydrodynamics and Structural Mechanics of the Lateral Line System Fish Biomechanics, 10.1016/S1546-5098(05)23004-2, (103-139), . Zeddies D and Siegel J (2004) A biophysical model of an inner hair cell, The Journal of the Acoustical Society of America, 10.1121/1.1755237, 116:1, (426-441), Online publication date: 1-Jul-2004. Gillespie P and Cyr J (2004) Myosin-1c, the Hair Cell's Adaptation Motor, Annual Review of Physiology, 10.1146/annurev.physiol.66.032102.112842, 66:1, (521-545), Online publication date: 1-Mar-2004. Bian L, Linhardt E and Chertoff M (2004) Cochlear hysteresis: Observation with low-frequency modulated distortion product otoacoustic emissions, The Journal of the Acoustical Society of America, 10.1121/1.1690081, 115:5, (2159-2172), Online publication date: 1-May-2004. Carvalho S, Mom T, Gilain L and Avan P (2004) Frequency specificity of distortion-product otoacoustic emissions produced by high-level tones despite inefficient cochlear electromechanical feedback, The Journal of the Acoustical Society of America, 10.1121/1.1777873, 116:3, (1639-1648), Online publication date: 1-Sep-2004. He D, Jia S and Dallos P (2004) Mechanoelectrical transduction of adult outer hair cells studied in a gerbil hemicochlea, Nature, 10.1038/nature02591, 429:6993, (766-770), Online publication date: 1-Jun-2004. Farris H, LeBlanc C, Goswami J and Ricci A (2004) Probing the pore of the auditory hair cell mechanotransducer channel in turtle, The Journal of Physiology, 10.1113/jphysiol.2004.061267, 558:3, (769-792), Online publication date: 1-Aug-2004. Shen Z, Liang F, Hazen-Martin D and Schulte B (2004) BK channels mediate the voltage-dependent outward current in type I spiral ligament fibrocytes, Hearing Research, 10.1016/S0378-5955(03)00345-9, 187:1-2, (35-43), Online publication date: 1-Jan-2004. van Netten S, Dinklo T, Marcotti W and Kros C (2003) Channel gating forces govern accuracy of mechano-electrical transduction in hair cells, Proceedings of the National Academy of Sciences, 10.1073/pnas.2632626100, 100:26, (15510-15515), Online publication date: 23-Dec-2003. Vollrath M and Eatock R (2003) Time Course and Extent of Mechanotransducer Adaptation in Mouse Utricular Hair Cells: Comparison With Frog Saccular Hair Cells, Journal of Neurophysiology, 10.1152/jn.00893.2002, 90:4, (2676-2689), Online publication date: 1-Oct-2003. Kennedy H, Evans M, Crawford A and Fettiplace R (2003) Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells, Nature Neuroscience, 10.1038/nn1089, 6:8, (832-836), Online publication date: 1-Aug-2003. Eatock R and Hurley K (2003) Functional Development of Hair Cells , 10.1016/S0070-2153(03)57013-2, (389-448), . Rybalchenko V and Santos-Sacchi1 J (2003) Cl- flux through a non-selective, stretch-sensitive conductance
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