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Relationship between plasma concentrations of immunoreactive beta-endorphin and food intake in rats

1983; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês

10.1016/0196-9781(83)90170-5

1873-5169

J. Mark Davis, M T Lowy, G.K.W. Yim, D. R. Lamb, P.V. Malven,

Regulation of Appetite and Obesity

Periods of increased food intake in male rats were characterized by significant elevations in the plasma concentrations of immunoreactive beta-endorphin (β-ep). Administration of 2-deoxy-D-glucose (400 mg/kg) produced rapid and concurrent increases in both food intake and plasma β-ep. Administration of insulin (10 units/kg) produced large delayed increases in food intake but only modest delayed increases in plasma β-ep. Spontaneous nocturnal feeding was associated with increased plasma β-ep. Increases in daytime food intake in rats subjected to 24 hr of food deprivation were also characterized by elevated plasma β-ep. In all cases examined, those feeding behaviors in male rats which were subject to inhibition by naloxone were characterized by elevated concentrations of plasma β-ep.