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Neoadjuvant endocrine therapy in primary breast cancer: indications and use as a research tool

2010; Springer Nature; Volume: 103; Issue: 6 Linguagem: Inglês

10.1038/sj.bjc.6605845

1532-1827

Yee Hong Chia, Matthew J. Ellis, C X,

Estrogen and related hormone effects

Neoadjuvant endocrine therapy has been increasingly employed in clinical practice to improve surgical options for postmenopausal women with bulky hormone receptor-positive breast cancer. Recent studies indicate that tumour response in this setting may predict long-term outcome of patients on adjuvant endocrine therapy, which argues for its broader application in treating hormone receptor-positive disease. From the research perspective, neoadjuvant endocrine therapy provides a unique opportunity for studies of endocrine responsiveness and the development of novel therapeutic agents.