Primary thrombophilia in Mexico: A prospective study
1999; Wiley; Volume: 60; Issue: 1 Linguagem: Inglês
10.1002/(sici)1096-8652(199901)60
ISSN1096-8652
AutoresGuillermo J. Ruiz-Arg�elles, Sonia Gonz�lez-Estrada, Javier Garc�s-Eisele, Alejandro Ruiz-Arg�elles,
Tópico(s)Coagulation, Bradykinin, Polyphosphates, and Angioedema
ResumoA group of 102 Mexican Mestizo patients with appropriate clinical features suggestive of primary thrombophilia was prospectively studied. Thirty-nine percent of them had activated protein C resistance, but only four patients displayed the factor V Leiden mutation. Five percent of the individuals were found to be protein C deficient, whereas 2% had protein S deficiency. No cases of abnormalities in antithrombin III, plasminogen, tissue-type plasminogen activator or plasminogen activator inhibitor were found. The low prevalence of the activated protein C resistance genotype, probably stemming from the genetic admixture of the Mexican Mestizo group is noteworthy. Am. J. Hematol. 60:1–5, 1999. © 1999 Wiley-Liss, Inc.
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