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Efficacy, tolerability, and rare side effects of tibolone treatment in postmenopausal women

1999; Elsevier BV; Volume: 64; Issue: 3 Linguagem: Inglês

10.1016/s0020-7292(99)00002-8

1879-3479

Christian Egarter, Michael Sator, Peter Berghammer, J. Huber,

Endometriosis Research and Treatment

Abstract Objective : The purpose of this study was to assess the tolerability and side effects of tibolone (Livial ® , Organon), a synthetic steroid analogue for the treatment of postmenopausal symptoms, in a large population of patients. Method : 1189 postmenopausal patients were included in this study. The patients' blood pressure, body weight, general complaints, and the severity of their climacteric complaints were documented at baseline and after 4 months of tibolone treatment. Results : Tibolone significantly relieved all of the classical menopausal complaints. The proportion of patients with bleeding problems dropped significantly from 15.9% to 6.8%. Other complaints, such as headache, vertigo, nervousness, breast tenderness, and hirsutism were also significantly less frequent than before treatment. Only few women reported other rare side effects, and only 14.4% of women discontinued treatment prematurely. Conclusion : Tibolone provides an efficient and safe means of treating the postmenopausal syndrome in every‐day practice.