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Methylamine deprotection provides increased yield of oligoribonucleotides

1995; Elsevier BV; Volume: 36; Issue: 49 Linguagem: Inglês

10.1016/0040-4039(95)01953-f

1873-3581

M. P. Reddy, Firdous Farooqui, Naeem B. Hanna,

Biopolymer Synthesis and Applications

Use of methylamine or methylamine/ammonium hydroxide as a cleavage and deprotection reagent for the solid phase synthesis of Oligoribonucleotides has significantly increased the yield of the full length Oligoribonucleotides as compared to the use of conventional ammonium hydroxide/ethanol.