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Effect of dipyrone, acetylsalicylic acid and acetaminophen on human neutrophil chemotaxis

1984; Wiley; Volume: 14; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2362.1984.tb01210.x

1365-2362

Yaacov Matzner, Ruth Drexler, Micha Levy,

S100 Proteins and Annexins

Abstract. Dipyrone metabolites 4‐methylaminoantipyrine (MAA) and 4‐formylaminoantipyrine (FAA) as well as acetylsalicylic acid inhibited neutrophil migration toward zymosan‐activated serum. Inhibition was maximal (76·8 pL 19·0; 79·2 pL 12·5 and 80·0 pL 4·4%, respectively, P < 0·003) when suboptimal concentrations (0·3%) of the chemoattractant were used and could be demonstrated with drug concentrations comparable with plasma concentrations obtained in clinical use. Acetaminophen and other dipyrone metabolites 4‐aminoantipyrine (AA) and 4‐acetylaminoantipyrine (AAA) lacked chemotactic inhibitory potential. Only MAA and FAA inhibited mildly neutrophil random migration (18·1 pL 7·8 and 11·2 pL 3·4%, respectively). We suggest that blocking neutrophil movement plays a role in the anti‐inflammatory activity of dipyrone and acetylsalicylic acid, but their mechanism of inhibition remains obscure.