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Quantitative analysis of murine terminal erythroid differentiation in vivo: novel method to study normal and disordered erythropoiesis

2013; Elsevier BV; Volume: 121; Issue: 8 Linguagem: Inglês

10.1182/blood-2012-09-456079

1528-0020

Jing Liu, Jianhua Zhang, Yelena Ginzburg, Huihui Li, Fumin Xue, Lucia De Franceschi, Joel Anne Chasis, Narla Mohandas, Xiuli An,

Blood groups and transfusion

Key Points The study establishes a reliable method to quantify differentiating mouse erythroblasts and to monitor terminal mouse erythropoiesis in vivo. Quantitative analysis of erythropoiesis of thalassemia mice revealed stage-specific changes in terminal erythroid differentiation.