Synthesis and Anti-Mycobacterial Activity of N-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives
2005; Bentham Science Publishers; Volume: 2; Issue: 7 Linguagem: Inglês
10.2174/157018005774479131
ISSN1875-628X
AutoresIvan Neves Júnior, Maria Helena Lourenço, Maria das Graças Henriques, B.J.M. Leite Ferreira, T.R.A. Vasconcelos, Mônica A. Peralta, Pedro de Oliveira, J.L. Wardell, Marcus de Souza,
Tópico(s)Synthesis and Biological Evaluation
ResumoA series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.
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