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Screening of flavonoid “quercetin” from the rhizome of Smilax china Linn. for anti–psoriatic activity

2012; Medknow; Volume: 2; Issue: 4 Linguagem: Inglês

10.1016/s2221-1691(12)60021-5

2588-9222

A. Vijayalakshmi, V. Ravichandiran, Malarkodi Velraj, S Nirmala, Jaya Kumari,

Natural product bioactivities and synthesis

Objective: To assess anti-psoriatic activity of the methanol extract and the isolated flavonoid quercetin from the rhizome of Smilax china (S. china) Linn.Methods: Mouse tail test was used for the evaluation of anti-psoriatic activity.Methanol extract (100 and 200 mg/kg b.w.) and isolated flavonoid quercetin (25 and 50 mg/kg b.w.) were tested in Swiss albino mice.Parameters studied in the mouse tail test were changes in epidermal thickness and percentage orthokeratotic values.The anti-inflammatory role of the methanol extract and isolated flavonoid quercetin was evaluated using carrageenan-induced pleurisy in rats.In vitro antiproliferant assay on HaCaT cell lines was also carried out.Results: The isolated flavonoid quercetin from the rhizome of S. china produced significant orthokeratosis (P<0.01) in the mouse tail test.In epidermal thickness, a significant reduction with respect to control was observed in groups treated with retinoic acid and isolated flavonoid quercetin.The methanol extract (200 mg/kg) and isolated flavonoid quercetin (50 mg/kg) showed anti-inflammatory effect in terms of significant inhibition (P<0.001) in leukocyte migration.Maximum antiproliferant activity was shown by isolated flavonoid quercetin (IC 50 , 62.42暲10.20 毺g/mL).Conclusions: From the above data, the flavonoid quercetin shows significant orthokeratosis, anti-inflammatory and maximum antiproliferant activities.To our knowledge, this is the first report on the anti-psoriatic effect of the flavonoid quercetin which is promising for further investigations to prove its anti-psoriatic activity.