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Studies on the sesquiterpenoids of Panax ginseng C.A. Meyer. Isolation and structure determination of sesquiterpene alcohols, panasinsanols A and B.

1987; Pharmaceutical Society of Japan; Volume: 35; Issue: 5 Linguagem: Inglês

10.1248/cpb.35.1975

1347-5223

Hisakatsu Iwabuchi, Masahiro Yoshikura, Yoshitomi Ikawa, Wasuke Kamisako,

Biological Activity of Diterpenoids and Biflavonoids

Two sesquiterpene alcohols, panasinsanol A (1) and panasinsanol B (2), were isolated from the rootlets of Panax ginseng C. A. MEYER (Araliaceae) together with known sesquiterpene hydro-carbons, α-panasinsene (3), β-panasinsene (4), α-neoclovene (5), and β-neoclovene (6). The structures of 1 and 2 were established by spectral evidence, chemical correlations to congener hydrocarbons (3, 4, 5, and 6), and finally by their syntheses from (-) -β-caryophyllene. This is the first isolation of 1 from a natural source, and 2 is a novel panasinsane-type sesquiterpene.