Portal de Periódicos da CAPES

The Genotype-Tissue Expression (GTEx) project

2013; Nature Portfolio; Volume: 45; Issue: 6 Linguagem: Inglês

10.1038/ng.2653

1546-1718

John T. Lonsdale, Jeffrey Thomas, Mike Salvatore, Rebecca Phillips, Edmund Lo, Saboor Shad, Richard Hasz, Gary Walters, Fernando U. Garcia, Nancy Young, Barbara A. Foster, Mike Moser, Ellen Karasik, Bryan M. Gillard, Kimberley Ramsey, Susan Sullivan, Jason Bridge, Harold I. Magazine, John Syron, Johnelle Fleming, Laura A. Siminoff, Heather M. Traino, Maghboeba Mosavel, Laura K. Barker, Scott D. Jewell, Dan Rohrer, Dan Maxim, Dana Filkins, P.R. Harbach, Eddie Cortadillo, Bree D. Berghuis, Lisa Turner, Eric A. Hudson, Kristin Feenstra, Leslie H. Sobin, James Robb, Phillip Branton, Greg E. Korzeniewski, Charles Shive, David E. Tabor, Liqun Qi, Kevin Groch, Sreenath Nampally, Steve Buia, Angela Zimmerman, Anna M. Smith, Robin Burges, Karna Robinson, Kim Valentino, Deborah Bradbury, Mark Cosentino, Norma Diaz-Mayoral, Mary Kennedy, Theresa Engel, Penelope Williams, Kenyon Erickson, Kristin Ardlie, Wendy Winckler, Gad Getz, David S. DeLuca, Daniel G. MacArthur, Manolis Kellis, Alexander Thomson, Taylor Young, Ellen Gelfand, Molly Donovan, Yan Meng, George Grant, Deborah C. Mash, Yvonne Marcus, Margaret J. Basile, Jun S. Liu, Jun Zhu, Zhidong Tu, Nancy J. Cox, Dan L. Nicolae, Eric R. Gamazon, Hae Kyung Im, Anuar Konkashbaev, Jonathan K. Pritchard, Matthew Stevens, Timothée Flutre, Xiaoquan Wen, Emmanouil T. Dermitzakis, Tuuli Lappalainen, Roderic Guigó, Jean Monlong, Michael Sammeth, Daphne Koller, Alexis Battle, Sara Mostafavi, Mark I. McCarthy, Manual Rivas, Julian Maller, Ivan Rusyn, Andrew B. Nobel, Fred A. Wright, Andrey A. Shabalin, Mike Feolo, Nataliya Sharopova, Anne Sturcke, Justin Paschal, James M. Anderson, Elizabeth L. Wilder, Leslie Derr, Eric D. Green, Jeffery P. Struewing, Gary Temple, Simona Volpi, Joy T Boyer, Elizabeth J. Thomson, Mark S. Guyer, Cathy Ng, Assya Abdallah, Deborah Colantuoni, Thomas R. Insel, Susan E. Koester, A. Roger Little, Patrick K. Bender, Thomas Lehner, Yin Yao, Carolyn C. Compton, Jimmie B. Vaught, Sherilyn J. Sawyer, Nicole C. Lockhart, Joanne P. Demchok, Helen Moore,

Genomics and Chromatin Dynamics

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.